introduction liver abscess developing during hospital stay in pediatric patients on dialysis for acute kidney injury has been previously unreported. impaired immunity, prolonged use of antibiotics, diabetes and malnutrition predispose to liver abscess in chronic hemodialysis patients. case presentation we reported a case of liver abscess developing in a 6-year-old boy admitted with sepsis and m...

Liver dysfunction plays a significant role in the Intensive Care Unit (ICU) patients’ morbidity and mortality. Metabolic, hemodynamic and inflammatory factors contribute in liver damage. Hemorrhagic shock, septic shock, multiple organ dysfunction, acute respiratory dysfunction, metabolic disorders, myocardial dysfunction, infection from hepatitis virus, and therapeutic measures such as blood tr...

Parvovirus B19 has been associated with different diseases, such as erythema infectiosum, arthropathy and transient aplastic crisis. However, parvovirus B19 infection presenting as hepatic dysfunction and myelosuppression is rarely reported in adult patients. Herein, we report an adult case of acute parvovirus B19 infection presented with acute liver failure and myelosuppression. After being tr...

T HE liver plays a key role in the synthesis of proteins, metabolism of toxins and drugs, and in modulation of immunity. In critically ill patients, hypoxic, toxic, and inflammatory insults can affect hepatic excretory, synthetic, and/or purification functions, leading to systemic complications such as coagulopathy, increased risk of infection, hypoglycemia, and acute kidney injury. In severe c...

We report a case involving a rescued low birth weight infant (LBWI) with acute liver failure. CASE The patient was 1594 g and 323/7 gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transf...

conclusions pain management in patients with liver dysfunction is always challenging to physicians because of the adverse reactions of drugs, especially opioids. opioids should be used cautiously since they can cause sedation, constipation and sudden encephalopathy effects. since the clearance of these drugs in patients with hepatic insufficiency is decreased, the initial dose must be decreased...

background: closantel is a veterinary drug used as anthelmintic for ruminants while it is contraindicated for humans. this report describes a rare case of blindness, increased liver enzymes and coagulopathy following closantel poisoning. case report: a 5-year-old girl was presented with acute blindness following closantel poisoning. she was given mistakenly a dose of 500 mg/day (25mg/kg/day) fo...

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Innate and adaptive immune dysfunction, also referred to as cirrhosis-associated immune dysfunction syndrome, is a major component of cirrhosis, and plays a pivotal role in the pathogenesis of both the acute and chronic worsening of liver function. During the evolution of the disease, acute decompensation events associated with organ failure(s), so-called acute-on chronic liver failure, and chr...