Human acute lymphoblastic leukemia cells have been estab lished as a serially transplantable lymphosarcoma in newborn Syrian hamsters by the direct inoculation of cells from the peripheral blood of a boy in the terminal stages of lympho sarcoma. The experimental neoplasm, currently in its 70th serial passage, is metastatic and occasionally progresses to frank leukemia. In later passages, it has...

with CMV infections (21 , 26). These observations have been supported by studies from a number of laboratories utilizing a murine experimental model of acute CMV infection. Lympho cyte responses have been shown to be depressed to various Tand B-cell mitogens during the acute phase of MCMV infection (1, 10, 12, 28). Depression of other parameters of lymphocyte function has also been noted during...

these patients, in general, have a more aggressive form of disease (2, 28, 29). Most patients have lymphoblasts that lack identifiable surface markers. Thus, the subcategories of acute Iymphocytic leukemia in humans probably repre sent proliferation of different clones of lymphoblasts. There are known differences in glucocorticoid susceptibility among functional subcategories of lymphocytes in ...

IN this paper we are concerned, not with the simple tumours-fibroma, lipoma, lymphangioma, lymphosarcoma, round-cell sarcoma-which occasionally (though rarely) arise in the thymus, as in other parts of the body, but with those which arise from the essential epithelioid cells of the thymic medulla associated in greater or lesser proportion with lymphocyte-like cells (probably really lymphocytes)...

Thymic lymphoma is a very common spontaneous and/or induced malignancy in both inbred mice and in transgenic mouse models of human cancer. Although a thymic lymphoma is defined as thymus-dependent T-cell malignancy, diagnostic criteria vary between studies and considerable heterogeneity has been reported. To define and classify the thymic lymphomas that arose in our study of X-irradiated (CBA/H...

Background: Men who were part of an Australian petroleum industry cohort had previously been found to have an excess of lympho-hematopoietic cancer. Occupational benzene exposure is a possible cause of this excess. Methods: We conducted a case-control study of lympho-hematopoictic cancer nested within the existing cohort study to examine the role of benzene exposure. Cases identified between 19...