Acute leukaemia of ambiguous lineage (ALAL) is a rare form of leukaemia in which morphologic, cytochemical and immuno-phenotypic features of the proliferating blasts lack sufficient evidence to classify them as myeloid or lymphoid in origin or have characteristics of both myeloid and lymphoid cells. We report a 22-year-old man presenting with clinical features of an acute lymphoblastic leukaemi...

Acute lymphoblastic leukaemia (ALL) accounts for about 78% of all leukaemia diagnosed in children. ALL is the most common cancer in children [2] . Acute myeloid leukaemia (AML) is the next most common and accounts for 15% of childhood leukaemia. The incidence rates are highest in infants (under 1 year old) and show little variation from age 3 years onwards. Chronic myeloid leukaemia (CML) accou...

Fifty-three patients with chronic myeloid leukaemia (CML) were included in this study (25 females & 28 males) and followed-up from October 2003 till October 2005 included for the evidence of acute transformation. Twenty-one patients (39.6%) transformed to acute phase , 16 patients(76.1%) of them transformed during the first 4 years of diagnosis. Fifteen patients (71.4 %) ) transformed to acute ...

OBJECTIVE To analyse a decade-long pattern of clinical presentation of acute myeloid leukaemia patients and compare it with contemporary data. METHODS The retrospective cohort study was conducted at the National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, and comprised of medical record of acute myeloid leukaemia patients from March 2006 to October 2016. Data noted a...

Myeloid or type 1 dendritic cell leukaemia is an exceedingly rare haematopoietic neoplasm characterized by a specific immunophenotypic profile close to plasmacytoid dendritic cell and acute myelogenous leukaemia. A 77-year-old man presenting specific cutaneous infiltration by myeloid dendritic cell leukaemia is reported. The clinical features as well as the cutaneous histopathological and immun...

A patient with rapidly fatal septic shock caused by group G beta-haemolytic streptococci as presenting symptom of acute myeloid leukaemia is presented. Although the association of septic shock due to Group G beta-haemolytic streptococci and different kinds of malignancy is known, presentation of acute myeloid leukaemia in this form is rare.

Lysosomal enzyme activities were studied in cells derived from the following types of leukaemia: chronic myeloid, acute myeloid, acute myelomonocytic, acute monocytic, non-T, non-B cell acute lymphoblastic, T-cell acute lymphoblastic, B-cell chronic lymphocytic and T-cell chronic lymphocytic. Activities of beta-hexosaminidase and alpha-mannosidase were significantly higher in cells from acute m...

Haematological neoplasms comprise a collection of heterogeneous neoplastic conditions that arise from cells the bone marrow and lymphoid system. This study describes pattern distribution haematological at tertiary hospital inNorthernProvince,Sri Lanka. A descriptive retrospective audit was conducted ofall diagnosed by peripheral blood examination. total 435 were reported during 4-year period. A...

Chloroma, also called Granulocytic Sarcoma or Myeloid Sarcoma, is a rare malignant extra-medullary neoplasm of myeloid precursor cells. It is usually associated with myelo-proliferative disorders but its appearance may precede the onset of leukaemia. Chloroma may be found in several extracranial sites. Involvement of the head and neck region is uncommon. Differential diagnosis is often difficul...