Infusion of the chemotherapeutic agent oxaliplatin leads to an acute and a chronic form of peripheral neuropathy. Acute oxaliplatin neuropathy is characterized by sensory paresthesias and muscle cramps that are notably exacerbated by cooling. Painful dysesthesias are rarely reported for acute oxaliplatin neuropathy, whereas a common symptom of chronic oxaliplatin neuropathy is pain. Here we exa...

Acute peripheral neuropathy is dose limiting toxicity of oxaliplatin, a wildly used chemotherapeutic drug in colorectal cancer. The present study aimed to identify the relationship between pretreatment serum magnesium concentration and the acute oxaliplatin-induced peripheral neuropathy. We enlisted 318 colorectal cancer patients who received adjuvant or first-line oxaliplatin-based chemotherap...

INTRODUCTION Campylobacter species represent the main cause of bacterial diarrhea in developed countries and one of the most frequent causes of enterocolitis in developing ones. In some patients, Campylobacter jejuni infection of the gastrointestinal tract has been observed as an antecedent illness of acute motor axonal neuropathy, a variant of Guillain-Barré syndrome. CASE PRESENTATION We pr...

SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, in...

We report a patient with acute lymphoblastic leukemia who developed severe atypical neuropathy (SAN), distinct from classical vincristine neuropathy, following the use of vincristine and granulocyte colony-stimulating factor (G-CSF). SAN was characterized by acute onset of severe pain, exquisite tenderness on even light touch and profound motor weakness involving predominantly the lower limbs. ...

Radial artery thrombosis is a rare complication of cannulation. There are no reported cases of acute thrombosis and severe acute neuropathy in the setting of cannula discontinuation. We report a case of acute radial nerve mono-neuropathy following thrombosis after radial arterial line removal. The thrombus was immediately evident on exam and diagnostic imaging after cannula discontinuation. The...

PURPOSE To report a patient with Behcet disease presenting with acute optic neuropathy. METHODS A 47-year-old man was admitted to the authors' clinic owing to sudden visual loss in the left eye. Ophthalmologic and systemic examinations were performed. RESULTS Visual acuity was 4/10 in the left eye. Fundus examination demonstrated swollen optic disc with blurred margins. There was relative a...

Ten patients (14 eyes) with chronic simple glaucoma are described, each with features atypical for this disease and more suggestive that each had suffered an acute ischaemic optic neuropathy. Diagnosis of an acute ischaemic optic neuropathy in these cases is important, as treatment of ocular hypertension in the contralateral 'normal' eye may prevent a similar attack. Optic nerve disease and vis...

Kikkawa T, Takashima A. Practice of gait training using lower-limb orthosis and body weight-supported walker for severe acute motor axonal neuropathy: a case report. Jpn J Compr Rehabil Sci 2023; 14: 49-53.

DPN can present with a wide range of symptoms, including pain, unsteadiness, weakness, postural hypotension, gastroparesis, and impotence. It can lead to foot ulceration, Charcot foot, and amputation. It is desirable to periodically assess for the presence of neuropathy and also stratify neuropathy in patients in anticipation of these problems. It is important to be aware of the strengths and l...