A series of monoclonal antibodies reactive with normal myeloid cells at different stages of differentiation (anti-MY4, -MY7, -MY8, -Mo1, -Ia) were used to characterize the leukemic cells of 70 patients with acute myeloblastic leukemia (AML). Sixty-two of the leukemias expressed a phenotype corresponding to a recognizable immature normal myeloid cell. These 62 cases could be divided into 4 pheno...

background: acute lymphoblastic leukemia (all) is the most common form of childhood cancer leading to cancer-related death in children. most infants with all harbor recurring structural chromosomal rearrangements that are important initiating events in leukemogenesis but are insufficient to explain the biology and heterogeneity of the disease. mixed-lineage leukemia-rearrangement (mll-rearrange...

calcium metabolic disorders, such as hypercalcemia is a potentially life-threatening disorder especially when coupled with an already compromised condition. the aim of this study was to determine the prevalence of metabolic calcium disorders in childhood cancers of patients admitted to the pediatric ward of vali-asr hospital from the year 2001-2008. the study was carried out by reviewing hospit...

Disseminated intravascular coagulopathy (DIC) (see Figure 1) is a complex, life-threatening condition that causes a hypercoagulative state, resulting in inappropriate activation of the coagulation cascade (see Figure 2). Activation of the coagulation cascade is triggered by the release of tissue factor (TF), a transmembrane glycoprotein (McCance & Huether, 2006). On release of TF, the coagulati...

mycotic infections have been commonly encountered in patients with hematological malignancies. the current study seeks the prevalence of actinomycete infection in patients suffering from blood cells malignancies. a hundred and fifty patients with some kinds of blood cells dyscrasia who underwent the bone marrow aspiration were recruited. in addition to the diagnostic work up, samples were exami...

midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. herein, we describe a case of acute pre b cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. at the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. our case sugg...

The occurrence of severe bleeding syndrome because the PML-RARα fusion protein is a life-threatening event in APL. This destabilizes homeostasis, maturation, remodeling, and tissue regeneration addition to hampering maintenance differentiation hematopoietic cells into different lineages, fixing promyelocyte stage. APL classic example how effective targeted therapy and, therefore, important use ...

Acute promyelocytic leukemia (APL) is characterized by a block to myeloid differentiation caused by expression of the fusion oncoprotein promyelocytic leukemia-retinoic acid receptor alpha (PML-RARalpha). The purpose of this study was to identify genes that are regulated in a PML-RARalpha-dependent fashion by retinoic acid (RA), because such genes may be integrally involved in APL pathogenesis ...

acute myeloblastic leukemia is one of the important malignancies in children. for better managing the prognosis of this disease, there should be enough information about common features of this malignancy. the aim of this study was to evaluate these common features in children with acute myeloblastic leukemia. a total of 104 eligible children less than 15-year-old have been referred from 2007-2...

Severe congenital neutropenia (SCN) is a hematologic condition characterized by arrested maturation of myelopoiesis at the promyelocyte stage of development (1). With appropriate treatment using recombinant human granulocyte colony-stimulating factor (r-HuG-CSF), patients with SCN are now surviving well past infancy. With longer survival, the high risk of developing myelodysplastic syndrome (MD...