STUDY DESIGN In vitro assays were performed with bone-forming cells isolated from 41 patients with adolescent idiopathic scoliosis and 17 control patients exhibiting another type of scoliosis or none. OBJECTIVE To determine whether a dysfunction of the melatonin-signaling pathway in tissues targeted by this hormone is involved in adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA P...

abstract   background: to evaluate proximal junctional segment changes in adolescent idiopathic scoliosis(ais) the posterior spinal fusion and also instrumentation also and finding of probable risk factors, were all considered in this study.   methods: we retrospectively reviewed radiographs of 121 consecutive patients who underwent posterior spinal fusion for ais from t3 or below, with a mean ...

BACKGROUND The etiology of idiopathic scoliosis remains unknown and different factors have been suggested as causal. Hereditary factors can also determine the etiology of the disease; however, the pattern of inheritance remains unknown. Autosomal dominant, X-linked and multifactorial patterns of inheritances have been reported. Other studies have suggested possible chromosome regions related to...

BACKGROUND Adolescent idiopathic scoliosis exhibits high heritability and is one of the most common spinal deformities found in adolescent populations. However, little is known about the disease-causing genes in families with adolescent idiopathic scoliosis exhibiting Mendelian inheritance. OBJECTIVE The aim of this study was to identify the causative gene in a family with adolescent idiopath...

Adolescent idiopathic scoliosis is defined as a lateral and rotational curvature of the spine with an unknown origin. Scoliosis is diagnosed based on age of onset and clinical presentation. Physicians measure curve severity by Cobb’s angle, which is marked on an x-ray. Participation is sports, which require compressive and tensile forces on the spine increase risk of back-related injury, includ...

[email protected] INTRODUCTION: The observation that an experimental pinealectomy in newborn chickens leads to a spinal deformity similar to idiopathic scoliosis in humans initiated a new neuroendocrine hypothesis for the cause of idiopathic scoliosis. A deficiency of melatonin, which is the principal product of the pineal gland, was believed to be responsible for this deformity, because b...

BACKGROUND There are no data on social acceptability of scoliosis. Aim. To elicit evidence-based opinions on therapeutic strategies for adolescent idiopathic scoliosis in a sample of families with not affected children, so to understand the social perception of this issue. METHODS Design. Cross-sectional study. Setting. Secondary schools in 4 northern Italian regions. Participants. Parents of...

OBJECTIVE To create a clinical database of respiratory function in patients with adolescent idiopathic scoliosis; computerize and store this clinical data through the use of a software; incorporate this electronic protocol to the SINPE© (Integrated Electronic Protocols System) and analyze a pilot project with interpretation of results. METHODS From the literature review a computerized data ba...

surgery on the skeleton frequently requires harvesting of autogenous bone graft from the pelvis, but this procedure often is complicated by problems. the purpose of this retrospective, comparative descriptive study was to compare the efficacy of metal-derived bioactive glass (novabone) versus autogenous iliac crest bone graft in adolescent idiopathic scoliosis surgery. the study was carried out...