Introduction: The ginger rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases. In the present study the effect of ginger alcoholic extract on mechanical activity of isolated jejunum of male rats and also its interaction with cholinergic, adrenergic and Nitrergic systems were investigated. Methods: Seven adult male Wistar rats were anesthetized by et...

introduction: oxytocin is a active neuropeptide of central nervous system. in this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (lc) nucleus were investigated. methods: adult male wistar rats were used. animals divided into different groups receiving saline, oxytocin...

?-adrenergic receptor antagonists (?-blockers) are extensively used to improve cardiac performance in heart failure (HF), but the electrical improvements with these clinical treatments not fully understood. The aim of this study was analyze electrophysiological effects system remodeling reduced ejection fraction and underlying mechanisms. We a combined mathematical model that integrated signali...

Introduction: Oxytocin is a active neuropeptide of central nervous system. In this study the effects of naloxone (opioid receptor antagonist) and yohimbine (α-2 adrenergic receptor antagonist) on analgesic effect of oxytocin applied into the locus coeruleus (LC) nucleus were investigated. Methods: Adult male Wistar rats were used. Animals divided into different groups receiving saline, oxy...

The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of sleep-wake cycle and synaptic plasticity. In Alzheimer’s disease, locus coeruleus degeneration is observed early in the course of the disease, yea...

Evidence that leptin regulates bone turnover in part through a central nervous system (CNS)/beta-adrenergic system relay has driven attention towards the potential therapeutic benefits of beta-adrenergic blockade to improve bone mass and strength. beta2- adrenergic receptor-mediated signaling in osteoblasts inhibits bone formation and triggers RANKL-mediated osteoclastogenesis and bone resorpti...

Objective - to study, the dynamics of catecholamine binding on erythrocytes when modeling stimulation and blockade adrenergic regulation mechanisms using cytological method
 Material methods. The number granules was determined silver nitrate impregnation under conditions administration anapriline -adrenergic receptor blocker (2 mg/kg), acute stress, activation noradrenergic systems (maprot...