The beneficial effects of treatment for lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH), or LUTS/BPH, have to be balanced against the morbidity associated with treatment. Invasive surgery, such as transurethral resection of the prostate, has been associated with irreversible complications (eg, impotence and retrograde ejaculation). Alpha(1)-adrenoceptor anta...

Recent evidence suggests that the quinazoline-based 1-adrenoceptor antagonists, doxazosin and terazosin, exhibit a potent apoptotic effect against prostate tumor epithelial cells, whereas tamsulosin, a sulfonamide-based 1-adrenoceptor antagonist, was ineffective in inducing a similar apoptotic effect against prostate cells (Cancer Res., 60: 4550–4555, 2000). In this study, to identify the preci...

METHODS. Isolated arteries from the intraocular part of the porcine ciliary artery were suspended in microvascular myographs for isometric tension recording. The segments were contracted with the a2-adrenoceptor agonists brimonidine, apraclonidine, and oxymetazoline. To determine which subtypes of the a2-adrenoceptor mediate this contraction, antagonists subselective for the different a2-adreno...

The β1-adrenoceptor exists in two agonist conformations/states: 1) a high-affinity state where responses to catecholamines and other agonists (e.g., cimaterol) are potently inhibited by β1-adrenoceptor antagonists, and 2) a low-affinity secondary conformation where agonist responses, particularly CGP12177 [(-)-4-(3-tert-butylamino-2-hydroxypropoxy)-benzimidazol-2-one] are relatively resistant t...

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. Physiology of Aqueous Humour and Intraocular Pressure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2. Medical Treatment of Glaucoma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

  There is evidence indicating that adrenoceptor mechanisms may influence some of the behaviors in rat. However the role of adrenoceptor agents on sniffing has not been identified. In the present study, the influence of adrenoceptor agents on sniffing induced by apomorphine and amphetamine has been investigated. Male Albino rats, weighing 150-250 g were used for all experiments. The behavior wa...

Pharmacological analysis alone has failed to clarify the role of the three alpha(1)-adrenoceptor subtypes in modulating vascular tone, due to a lack of sufficiently selective antagonists, particularly for the alpha (1B)-adrenoceptor, and the complexity when three receptor subtypes are potentially activated by the same agonist. We adopted a combined genetics/ pharmacology strategy based on the a...

Antagonists acting on the betaor alphaadrenoceptors are used widely in medicine and in anaesthesia. The major indications for betaadrenoceptor blockade are coronary artery disease and arterial hypertension, while those for alphaadrenoceptor blockade include arterial hypertension, paroxysmal hypertension and chronic cardiac failure. The adrenoceptor antagonists interfere with important regulator...