نتایج جستجو برای: afp

تعداد نتایج: 3606  

2013
Bin Hu Xiaohui Tian Jie Sun Xiangjun Meng

The clinical value of Serum alpha-fetoprotein (AFP) to detect early hepatocellular carcinoma (HCC) has been questioned due to its low sensitivity and specificity found in recent years. Other than AFP, several new serum biomarkers including the circulating AFP isoform AFP-L3, des-gamma-carboxy prothrombin (DCP) and Golgi protein-73 (GP73) have been identified as useful HCC markers. In this inves...

Amniotic fluid (AF) is essential for fetal development and maturation during pregnancy. The levels of proteins in AF have been determined in many studies to screen for potential biomarkers of pregnancy-associated abnormalities. Alpha-fetoprotein (AFP) is a major AF and plasma protein produced by the yolk sac and the liver during the fetal period. APF serum concentrations are commonly used for s...

2017
Sang Joon Park Jae Young Jang Soung Won Jeong Young Kyu Cho Sae Hwan Lee Sang Gyune Kim Sang-Woo Cha Young Seok Kim Young Deok Cho Hong Soo Kim Boo Sung Kim Suyeon Park Hae In Bang

Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). This study compared the diagnostic values of AFP, AFP-L3, and PIVKA-II individually and in combination to find the best biomarker or biomarker panel.Seventy...

Journal: :Japanese journal of clinical oncology 2002
Toshiyuki Kamoto Shinji Satomura Tatsuhiro Yoshiki Yusaku Okada Fumiyo Henmi Hiroyuki Nishiyama Takashi Kobayashi Akito Terai Tomonori Habuchi Osamu Ogawa

OBJECTIVE Alpha-fetoprotein (AFP) is an important tumor marker for non-seminomatous germ cell tumors (NSGCTs) that greatly affects diagnosis and the evaluations of therapy and therapeutic policy. However, it is sometimes very difficult to make the distinction between tumors and falsely elevated AFP levels due to benign liver disease. We assessed the usefulness of lectin-reactive alpha-fetoprote...

Journal: :Oncology reports 2011
Kohei Oda Akio Ido Tsutomu Tamai Masakaze Matsushita Kotaro Kumagai Sei-ichi Mawatari Akiko Saishoji Takeshi Kure Kaori Ohno Eriko Toyokura Dai Imanaka Akihiro Moriuchi Hirofumi Uto Makoto Oketani Teruto Hashiguchi Hirohito Tsubouchi

The fucosylated fraction of α-fetoprotein (AFP-L3) is a specific marker for hepatocellular carcinoma (HCC). However, conventional AFP-L3% (c-AFP-L3%) has not always been reliable in cases with low serum α-fetoprotein (AFP) levels. In this study, we evaluated the clinical utility of a newly developed assay, highly sensitive AFP-L3% (hs-AFP-L3%). Subjects included 74 patients with benign liver di...

2016
Aiying Zhang Sven Skog Shengqi Wang Yang Ke Yonghong Zhang Kang Li Ellen He Ning Li

The Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3) is widely used to screen for hepatocellular carcinoma (HCC) in Japan and China. We developed a chemiluminescent protein microarray for determining the AFP-L3/AFP index (the ratio of AFP-L3 to total AFP, AFP-L3%) by fixing AFP-specific antibodies and Lens culinaris lectin on aldehyde-coated glass slides. Serum samples were tested fo...

Journal: :Cancer research 1993
K Taketa Y Endo C Sekiya K Tanikawa T Koji H Taga S Satomura S Matsuura T Kawai H Hirai

Lectin-affinity electrophoretic separation of serum alpha-fetoprotein (AFP) was carried out using AFP Differentiation Kits, which used Lens culinaris agglutinin-A (Kit L) and erythroagglutinating phytohemagglutinin (Kit P). Separated AFP bands were detected with a sensitive antibody-affinity blotting technique and determined quantitatively by densitometry, and the results were expressed as perc...

2016
Zhiguo Zhang Yanying Zhang Yeying Wang Lingling Xu Wanju Xu

Currently, there is no reliable biomarker for use in diagnosing alpha-fetoprotein (AFP)-negative hepatocellular carcinoma (HCC). Such a biomarker would aid in making an early diagnosis of AFP-negative HCC, ensuring the timely initiation of treatment. This study examined AFP-L3 and Golgi protein 73 (GP73) as candidate biomarkers for AFP-negative HCC. The affinity adsorption method and enzyme-lin...

Journal: :Journal of perinatal medicine 1973
M Seppälä E Ruoslahti

Alpha fetoprotein (AFP) is synthesized by the x human fetal liver and yolk sac [8, 9]. During the 12—14 intrauterine weeks the serum concentration of AFP is at its highest, reaching a few milligrams per ml [7]. However, the total amount of AFP in the fetus increases until the 22 week of gestation, remaining constant until about the 32 week, and thereafter decreasing [7]. In the newborn at term,...

2017
Huaping Chen Siyuan Chen Shan Li Zhijian Chen Xuan Zhu Meiyu Dai Lingxi Kong Xiaodan Lv Zhili Huang Xue Qin

Controversies about the combination of des-gamma-carboxyprothrombin (DCP) and alpha-fetoprotein (AFP) for hepatocellular carcinoma diagnosing still exist. Hence, we performed this updated meta-analysis to estimate the diagnostic value of DCP , AFP and DCP + AFP in HCC. In addition, we conducted a validation study to analyze the performance of the candidate makers. After a systematic literature ...

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