PURPOSE Advanced glycation end products (AGEs) are non-enzymatic modifications of proteins or lipids after exposure to sugars. In this review, the glycation process and AGEs are introduced, and the harmful effects of AGEs in the aging process are discussed. METHODS Results from human and animal studies examining the mechanisms and effects of AGEs are considered. In addition, publications addr...

Two simple algorithms are suggested here to correct for the effect of diffusion and diagenetic sulfate reduction on radiocarbon age determination of marine porewater. The correction algorithms were developed from mass balances of sulfate, dissolved inorganic carbon (DIC), and 14C of the DIC (CDIC) in vertical concentrations profiles in porewater starting from the sediment water interface. The a...

BACKGROUND The magnitude of the benefit associated with screening has been debated. We present a meta-analysis of quasi-experimental studies on the effects of mammography screening. METHODS We searched MEDLINE/PubMed and Embase for articles published through January 31, 2013. Studies were included if they reported: 1) a population-wide breast cancer screening program using mammography with 5+...

extract   if you are young, old or in midlife your new ages activities have different meaning to past times.   same as the other societies in our society, age is one of the essential dimensions of organizations and social associations. for example our school system is based on the students' ages. student behavior is different of their adult teachers based on the ages. more or less families...

BACKGROUND Ex-drinkers suffer from worse health than drinkers; however, whether a worsening of health is associated with a change in drinking status from early adulthood has not been previously investigated. We assess whether a worsening of health is associated with a cessation in consumption or reduction to special occasion drinking from early adulthood to middle age. METHODS Multinomial log...

BACKGROUND During the last century, Kerala witnessed drastic mortality reduction and high improvement in longevity. This achievement is often compared with that of developed countries. However, how far the early advantages in mortality reduction have further enhanced in Kerala remains unknown. In most developed countries, advanced stage of mortality reduction and further increase in longevity w...

High performance concrete (HPC) requires a low water-to-cementitious materials mass ratio (w/cm), often with the inclusion of supplemental cementitious materials such as silica fume in the mixture, thus necessitating the use of a superplasticizer. Because of the low w/cm and rapid reaction at early ages, proper curing from the earliest time possible is very essential in HPC. Internal curing has...

Advanced glycation end products (AGEs) constitute a complex group of compounds produced endogenously during the aging process and under conditions of hyperglycemia and oxidative stress. AGEs also have an emerging exogenous origin. Cigarette smoke and diet are the two main exogenous sources of AGEs (glycotoxins). Modern Western diets are rich in AGEs which have been implicated in the pathogenesi...