Airway inflammation is fundamental to the cause and persistence of asthma and other airway conditions. It contributes to symptoms, variable airflow limitation, airway hyperresponsiveness, and the structural changes (remodeling) associated with asthma. However, the presence and type of airway inflammation can be difficult to detect clinically, delaying the introduction of appropriate treatment. ...

background: inverse relationship between helminths infection and immune-mediated diseases has inspired researchers to investigate therapeutic potential of helminths in allergic asthma. helminth unique ability to induce immunoregulatory responses has already been documented in several experimental studies. this study was designed to investigate whether excretory/secretory (es) and somatic produc...

Airway inflammation is fundamental to the aetiology and persistence of asthma and other airway conditions. The presence and type of airway inflammation can be difficult to detect clinically, delaying the introduction of appropriate treatment. Induced sputum cell counts are a relatively noninvasive, safe and reliable method of identifying airway inflammation. They can accurately discriminate eos...

Introduction Inflammatory airway disease (IAD) affects 25% to 30% of horses in training. These animals also frequently have upper airway inflammation that may predispose them to dorsal displacement of the soft palate (DDSP). The etiology of this airway inflammation remains obscure, but exposure to organic dusts may play a major role. Organic dusts originate from hay and bedding, and stabled hor...

 To provide an overview of airway inflammation in asthma.  To review current management guidelines’ recommendations for the use of anti-inflammatory therapies in asthma.  To discuss current treatment options for airway inflammation in asthma.  To outline unmet needs for treating airway inflammation in asthma.  To describe novel targets for treating airway inflammation in asthma based ...

BACKGROUND Airway hyperresponsiveness is the ability of airways to narrow excessively in response to inhaled stimuli and is a key feature of asthma. Airway inflammation and ventilation heterogeneity have been separately shown to be associated with airway hyperresponsiveness. A study was undertaken to establish whether ventilation heterogeneity is associated with airway hyperresponsiveness indep...

Background Bronchial asthma is traditionally viewed as an eosinophilic airway inflammatory disorder with the involvement of Th2 cytokines. In refractory asthma, where chronic inflammation and airway remodeling are key pathological features, it is suggested that the dysregulation of the Th1/Th2 cytokines production modifies airway inflammation and airway hyperrespnsiveness (AHR). Interleukin (IL...

BACKGROUND A DNA vaccine encoding the whole segment of the Derp2 allergen could prevent allergic airway inflammation in a Derp2 allergen-induced allergic airway inflammation mouse model. OBJECTIVE This study investigated the effect of DNA vaccine encoding Derp2-mutant gene in which an IgE epitope was deleted on airway inflammation and the role of TLR9 in the asthmatic mouse model. METHODS A...

Exposure to inhaled allergens leads to increases in airway hyperresponsiveness (AHR) and inflammation, associated with increased levels of biologically active fragments derived from the complement C3 and C5 family of proteins. Further, complement activation during allergen challenge in sensitized animals is necessary for the development of AHR and airway inflammation. To define the complement p...