Objective: This study was done on 40 male wistar rats to evaluate the curative and protective effect of grape seeds extract on oxidative damage, inflammatory and apoptotic insult on lung tissue induced by cadmium chloride toxicity. Materials and Methods: The rats were classified to control group (group I), cadmium chloride group (group II), grape seeds extract group (group III) and mixture of g...

PURPOSE The purpose of this study was to investigate the effects of the hydro-alcoholic extract of Rhus coriaria seeds on the reproductive system of nicotinamide-streptozotocin-induced type-2 diabetic mice. MATERIALS AND METHODS In this experimental study, 56 male Naval Medical Research Institute mice were randomly divided into seven groups (n=8): control; diabetic mice; diabetic mice adminis...

Proanthocyanidins, extracted from grape seeds, are widely used mainly as nutritional supplements. However, there has not been a systematic report to investigate toxicological studies on proanthocyanidins, especially in oral administration. In our studies, proanthocyanidin-rich extract from grape seeds was subjected to a series of toxicological tests to document its safety for use in various foo...

INTRODUCTION Streptococcus mutans has been implicated as primary microorganisms which cause dental caries in humans. There has been an increased interest in the therapeutic properties of some medicinal plants and natural compounds which have demonstrated antibacterial activities. Grape is one of the plants of this group which contains tannin and polyphenolic compound. AIM To evaluate and comp...

Background Exposure to glucocorticoids such as dexamethasone (Dex) leads to numerous changes in various biological systems including the reproductive system .The present study investigates the efficacy grape seeds , source of the most useful groups of plant flavonoids, phenolic procyanids, to attenuate Dex-induced spetmatogenic defects in the mouse testicles. MaterialsAndMethods A total of 32 m...

Due to the increasing emergence of drug resistant Tuberculosis (TB), particularly multidrug resistant TB (MDR-TB), extensive-drug resistant TB (XDR-TB) and also the development of resistance in the micro-organisms against available drugs there is a need to develop new, potent, fast-acting antibacterial and antitubercular drugs with low toxicity. With this aim different extracts of Phaseolus vul...

Background and Objective: Recent studies have shown that anticholinergic alkaloids compounds have strong analgesic effects. Due to presence of anticholinergic alkaloids in Hyoscyamus niger and its mentioned effects in Iranian traditional medicine, its analgesic effects were assessed. At first, acute and chronic pain thresholds in male NMRI rats with formalin test was evaluated, then oral and in...

background and objective: recent studies have shown that anticholinergic alkaloids compounds have strong analgesic effects. due to presence of anticholinergic alkaloids in hyoscyamus niger and its mentioned effects in iranian traditional medicine, its analgesic effects were assessed. at first, acute and chronic pain thresholds in male nmri rats with formalin test was evaluated, then oral and in...

The aerial parts of Vitis vinifera Linn. (Common grape, Hindi ⎯ Angur) have been widely used in Ayurveda to treat a variety of common and stress related disorders. The seed extract of grapes was evaluated by Sreemantula and others for antistress activity in normal and stress induced rats. Furthermore, the extract was studied for nootropic activity in rats and in vitro antioxidant potential to c...