Objective: In this work, a gastro-retentive floating microsphere delivery system composed of Drug/Glyceryl mono-oleate (GMO) embedded in Ca-alginate gas-generated matrix was designed to improve the bioavailability slightly-soluble model drug Famotidine. Methods: The water/Oil emulsion method used prepare Famotidine floatable microspheres, and formulation variables such as Alginate: GMO ratio, b...

Alginate microspheres containing furosemide were prepared by the ionotropic external gelation technique using Ca2+, Al3+ and Ba2+ ions. The incorporation efficiency of the prepared microspheres ranged between 65% and 93%. The effect of sodium alginate concentration, cross-linking ions and drying conditions was evaluated with respect to entrapment efficiency, particle size, surface characteristi...

Soybean isoflavone (SIF) has anti-aging properties and many other biological functions; however, SIF is difficult to reach higher blood concentration due to its rapid metabolism. Therefore, it is of great value to design and produce a sustained-release formulation that is able to maintain a stable level of plasma concentrations. In this paper, soybean isoflavone sustained-release microsphere fr...

We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate hydrogel gelifying in situ would support spinal cord plasticity and functional recovery. The GDNF release from the hydrogel was slowed by GDNF encapsulation in microspheres compared to non-formulated GDNF (free GDNF). When injected in a rat spinal cord hemisection model, more neurofilaments were observe...

conclusions: the results of the present study indicated that oral preparation of cm with an acceptable taste is feasible. background: chlorpheniramine maleate (cm) is widely used as an antihistaminic drug but it is very bitter and as yet no mouth dissolving/disintegrating taste-masked preparation that might be useful for pediatric and geriatric patients is available in the market. objectives: t...

OBJECTIVE The objective of this study was to develop and characterize alginate microspheres suitable for embolization with on-demand triggered doxorubicin (DOX) release and whereby the microspheres as well as the drug releasing process can be visualized in vivo using MRI. METHODS AND FINDINGS For this purpose, barium crosslinked alginate microspheres were loaded with temperature sensitive lip...

Background: Different methods have been used for BCG vaccination. Alginate microspheres are useful in delivery of vaccines to the gastrointestinal tract by oral route. Objective: To compare the immune response following oral microencapsulated and subcutaneous (SC) route administration of BCG vaccine in BALB/c mice. Methods: Alginate microspheres were produced by an internal emulsification metho...

−Alginate microspheres incorporating poly(hydroxyethyl acrylate-co-coumaryl acrylate-co-2-ethylhexyl acrylate) (P(HEA-CA-EHA)) were prepared using the water droplets of W/O emulsion as a template. P(HEA-CAEHA) was prepared by a free radical reaction and the HEA/CA/EHA molar ratio was calculated to be 96.1 : 2.0 : 1.9 on the 1H NMR spectrum. The copolymer exhibited a lower critical solution temp...

BACKGROUND Minimally invasive glucose biosensors with increased functional longevity form one of the most promising techniques for continuous glucose monitoring. In the present study, we developed a novel nanoengineered microsphere formulation comprising alginate microsphere glucose sensors and anti-inflammatory-drug-loaded alginate microspheres. METHODS The formulation was prepared and chara...

This paper presents a drug delivery system based on alginate microspheres. The biocompatibility, the flexibility in size and shape, the ability to entrap biomolecules as well as cells make alginate based systems ideal for in vivo drug delivery. Specifically, considering the target application of neural regeneration and the issue of neuroprotection for the development of innovative neuroprosthes...