quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...

The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and TA1535 depended on the degree of substitution around the oxirane ring. Monosubstituted oxiranes were the most potent mutagens in both strains. 1...

Simple synthesis of modafinil derivatives and their biological activity are described. The key synthetic strategies involve substitution and coupling reactions. We determined the anti-inflammatory effects of modafinil derivatives in cultured BV2 cells by measuring the inhibition of nitrite production and expression of iNOS and COX-2 after LPS stimulation. It was found that for sulfide analogues...

The volatile oil obtained by hydrodistillation of the petals of Rosa damascena Mill. (Rosaceae) was analyzed by gas chromatography and gas chromatography/mass spectrometry (GC/MS). The yield of the oil was 0.12 % (v/w). Fifty compounds representing 99.06 % of the oil were characterized. The volatile oil was found rich in sesquiterpenes and aliphatic components, consisting of two monoterpenic es...

there is a great interest in developing rapid analytical methods and provide appropriate parametersfor quantitative analysis of compounds derived from refractory pollutants. such methods are important forroutine quality control analysis of an effluent before being discharged into the environment. therefore, a rapid methodology for identification and quantification of some aliphatic acids is pro...