نتایج جستجو برای: alk6
تعداد نتایج: 46 فیلتر نتایج به سال:
A murine distraction osteogenesis model was standardized to allow analysis of the molecular pathways associated with postnatal de novo bone formation. The authors examined the presence and expression of Bone Morphogenetic Proteins (BMPs) -2, -3, -4, -6 and -7, and the BMP receptors Alk3 and Alk6 at different stages. Strong signals were detected for BMP-4 at the end of the distraction period and...
Directing stem cells and progenitors towards neuronal differentiation – implications for experimental therapies for Parkinson’s disease Anke Brederlau Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Sahlgrenska Academy at Gothenburg University, Sweden. The insight that stemand progenitor-cells contribute to replacement of nerve cells in the adult central nervous syst...
Background: Evaluation of maturation genes expression and their pattern during in vitro culture of vitrified preantral follicles is an essential and could promote either vitrification procedure or culture condition. Materials and Methods: Preantral follicles (with 100- 130 μm diameter) isolated mechanically from 12-14 days old NMRI mice ovaries and divided into vitrification and control groups....
In Xenopus and zebrafish, BMP2, 4 and 7 have been implicated, after the onset of zygotic expression, in inducing and maintaining ventro-lateral cell fate during early development. We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in zebrafish. We show that Radar ventralizes zebrafish embryos and induces the earl...
Chick embryo extract (CEE) contains a variety of growth factors which may improve in vitro follicle growth. Therefore, the effect of CEE on mouse pre-antral follicle culture was evaluated. Different percentages of CEE (0, 0.50%, 1.00%, 5.00% and 10.00%) were added to culture medium. Hence, the osmolarity of media was measured. Pre-antral follicles with diameter of 120-150 μm were isola...
بیان ژنهای بلوغ و رسپتورهای آنها در طی بلوغ آزمایشگاهی توده های coc گوسفند در حضور سلولهای گرانولوزا
هدف این مطالعه بررسی اثر سیستم هم کشتی با سلولهای گرانولوزا مورال بر بلوغ توده های coc گوسفند بوده است، همچنین مراحل بلوغ هسته و سطح بیان ژنهای بلوغ و رسپتورهای آنها در دو مرحله ژرمینال وزیکول (gv) و متافاز دوم (mii) ارزیابی شد. توده های coc جدا شده از تخمدان بطور تصادفی به چهار گروه تقسیم شدند: در گروههای کنترل توده های coc به ترتیب بمدت 3 و 27 ساعت در محیط بلوغ قرار گرفتند (3h control and 27h...
Recent advances in genomic sequencing allow a new paradigm in hormonal research, and a comparative genomic approach facilitates the identification of receptors and signalling mechanisms for orphan ligands of the transforming growth factor beta (TGFbeta) superfamily. Instead of purifying growth differentiation factor 9 (GDF9) receptor proteins for identification, we hypothesized that GDF9, like ...
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta superfamily, play a variety of roles during mouse development. BMP type II receptor (BMPR-II) is a type II serine/threonine kinase receptor, which transduces signals for BMPs through heteromeric complexes with type I receptors, including activin receptor-like kinase 2 (ALK2), ALK3/BMPR-IA, and ALK6/BMPR-IB. To el...
The balance between tissue-type plasminogen activator (tPA) and one of its inhibitors, neuroserpin, has crucial roles in the central nervous system, including the control of neuronal migration, neuronal plasticity and neuronal death. In the present study, we demonstrate that the activation of the transforming growth factor-beta (TGFbeta)-related BMPR-IB (also known as BMPR1B and Alk6)- and Smad...
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