indolemine 2, 3-dioxygenase (ido) is a cytosolic monomeric hemoprotein enzyme that catalyses tryptophan, the least available essential amino acid in the human body, to n-formylkynurenine, which in turn rapidly degrades to give kynurenine. ido is expressed in different tissues, especially and prominently in some subsets of antigen presenting cells (apcs) of lymphoid organs and also in the placen...

isolated extramedullary relapse of chronic myelogenous leukemia (cml) after allogeneic stem cell transplant is rare. there is a case report of a child who developed a granulocytic sarcoma of the maxillary and sphenoid sinuses and lumbosacral spinal cord mass 18 months after allogeneic bone marrow transplant for cml. he was presented with per orbital edema and neurological deficit of lower extre...

Allogeneic hematopoietic stem cells transplantation is one of the effective methods treating patients with diseases blood system. Establishment complete (100%) donor chimerism among main indicators successful in such cases. Monitoring makes it possible both to assess graft acceptance, and also potentially predict risk developing primary/secondary failure, relapse, graft-versus-host disease. The...

introduction: the traditional goal of the treatment of acute myelogenous leukemia is to produce and maintain a complete remission (cr).the difference in survival time was entirely attributable to the duration of time spent in cr .in this study, the outcome of aml patients with allogeneic hsct in cr1 versus other than cr1 was compared. patients and methods: since march 1991 until november 2008, ...

hematology- oncology and stem cell transplantation research center related to tehran university of medical sciences located in shariati hospital. these center activities have started in 1991 in order to help needful patients and augment new data to reach new aspects of therapeutic trials. also it is one of the greatest stem cell transplantation centers in world and is the second center in the w...

Background: Burkitt lymphoma is a common subtype of non-Hodgkin lymphoma in children. It has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. Systemic chemotherapy is the mainstay of the treatment for this malignancy in children. In this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (HSC...

BACKGROUND The transfusion of allogeneic red blood cells and allogeneic coagulation products is associated with risk to the patient and the depletion of an increasingly scarce resource. This prospective, randomized, double-blind, placebo-controlled trial investigated practices to avoid transfusion in patients undergoing first-time cardiac surgery. METHODS Patients were randomized to one of th...

Allogeneic hematopoietic stem cell transplantation is the only curative treatment for many life-threatening diseases. Due to difficulty of finding an HLA-identical donor, from a haploidentical donor has become frequent alternative. This option associated with higher risk graft-versus-host disease (GVHD). In this article, we present current view on pathogenesis, and prevention GVHD report clinic...

several factors including cancer, malformations and traumas may cause large facial mutilation. these functional and aesthetic deformities negatively affect the psychological perspectives and quality of life of the mutilated patient. conventional treatments are prone to fail aesthetically and functionally. the recent introduction of the composite tissue allotransplantation (cta), which uses tran...