Blood transfusion in patients with sickle cell disease (SCD) is limited by the development of alloantibodies to erythrocytes. In the present study, the frequency and risk factors for alloimmunization were determined. Transfusion records and medical charts of 828 SCD patients who had been transfused and followed at the Belo Horizonte Blood Center, Belo Horizonte, MG, Brazil, were retrospectively...

ed blood cell (RBC) alloimmunization is a significant clincal complication of transfusion-dependent patients; it is elated to delays in obtaining matched blood as well as otentially life-threatening delayed hemolytic transfusion eactions (DHTRs), autoantibody formation, and hyperheolysis syndrome.1 Because of its critical significance, the henomenon of RBC alloimmunization has been investigated...

introduction: alloimmunization is a reaction of the immune system to foreign antigens. for prevention of alloantibody formation, performing of type and screen test is necessary on a patient's blood specimen as part of pre-transfusion testing. materials and method: in this cross-sectional study, type and screen test done for 1420 patients with elective surgery for detection of alloantibody in im...

This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC) (http:// creativecommons.org/licenses/by-nc/4.0/), which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes. For commercial reuse, contact [email protected]...

Background: Transfusion is the mainstay treatment of patients with thalassemia major and occasionally in thalassemia intermediate. Alloimmunization is an unwanted side effect of blood transfusion. The present study intended to determine the frequency of alloimmunization in patients with β- thalassemia major and thalassemia intermediate in Southwest Iran. Patients and Methods: This was a cross-...

Red blood cell alloimmunization remains a major complication for transfusion-dependent patients, but immune factors governing risk for alloimmunization are unknown. We hypothesized that CD4+ regulatory T cells (Tregs), which we have shown control the rate and the frequency of red blood cell alloimmunization in mouse models, may dictate responder/nonresponder status. Using a transfusion regimen ...

background: the development of anti-red blood cell alloantibodies remains a major problem in transfusion of blood in thalassemia major patients. also, autoantibodies can result in clinical hemolysis and difficulty in cross-matching blood. we studied the frequency of red blood cell alloimmunization and autoimmunization among thalassemia patients who received regular transfusions in ilam province...

Objectives The objective is to present a pregnancy complication associated with intravenous drug use, namely, that of red blood cell alloimmunization and hemolytic disease of the fetus and newborn. Methods An observational case series is presented including women with red blood cell alloimmunization most likely secondary to intravenous drug abuse Results Five pregnancies were identified that we...

OBJECTIVE To determine the distribution of ABO blood group and rhesus (RH) factor among pregnant women, to estimate the prevalence of Rh alloimmunization, and report the perinatal outcome of all cases of Rh alloimmunization at King Abdul-Aziz University Hospital (KAUH). METHODS This is a retrospective study of pregnant women attending the antenatal clinics in KAUH, Jeddah, Saudi Arabia betwe...

Background. Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients. Data about alloimmunization rate in general patient population is scarce especially from resource limited countries. We undertook this study to determine prevalence and specificity of RBC alloantibodies in patients admitted in various clinical specialties at a tertiary ...