This is a young premenopausal woman with a T1cN0 metaplastic breast cancer that is ER/PR Allred score 3, but negative by mRNA. Our recommendations are: adjuvant chemotherapy with TAC x 6 or dose-dense doxorubicin and cyclophosphamide followed by paclitaxel (ddAC-T). Whole-breast radiation therapy would follow. The patient could try tamoxifen, although the likelihood of benefit is very small.

G. Arpino, D.R. Ciocca, H. Weiss, D.C. Allred, P. Daguerre, L. Vargas-Roig, M. Leuzzi, F. Gago, R. Elledge, and S. K. Mohsin Baylor College of Medicine, Houston, Texas, USA; Institute of Experimental Medicine and Biology of Cuyo, Mendoza, Argentina; Hospital L. Lagomaggiore, Medical School, University of Cuyo, Mendoza, Argentina Hospital Italiano, Medical School, University of Cuyo, Mendoza, Ar...

http://nnr.sagepub.com/content/early/2007/12/11/1545968307308551 The online version of this article can be found at: DOI: 10.1177/1545968307308551 published online 11 December 2007 Neurorehabil Neural Repair Monica A. Maldonado, Rachel P. Allred, Erik L. Felthauser and Theresa A. Jones Ischemic Sensorimotor Cortex Lesions in Rats Motor Skill Training, but not Voluntary Exercise, Improves Recove...

BACKGROUND Adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) with fibrous stromal invasion are newly introduced subtypes of small lung adenocarcinoma. AIS is a small localized adenocarcinoma in which growth is restricted to neoplastic cells along preexisting alveolar structures without fibrous stromal invasion. In MIA, by contrast, tumor cells have infiltrated the myofibr...

Published Ahead of Print 9 October 2006. 10.1128/MCB.00260-06. 2006, 26(24):9302. DOI: Mol. Cell. Biol. Hadsell and Adrian V. Lee Ora L. Britton, Syed Mohsin, D. Craig Allred, Darryl L. Divisova, Kuiatse, Nicole A. Lawrence, Xiaomei Zhang, Jana Robert K. Dearth, Xiaojiang Cui, Hyun-Jung Kim, Isere Receptor Substrate 1 (IRS-1) or IRS-2 Caused by Overexpression of Insulin Mammary Tumorigenesis an...

Neurodegeneration 99 Defi ning SOD1 ALS natural history to guide therapeutic clinical trial design T Bali, W Self, J Liu, T Siddique, L H Wang, T D Bird, E Ratti, N Atassi, K B Boylan, J D Glass, N J Maragakis, J B Caress, L F McCluskey, S H Appel, J P Wymer, S Gibson, L Zinman, T Mozaffar, B Callaghan, A L McVey, J Jockel-Balsarotti, P Allred, E R Fisher, G Lopate, A Pestronk, M E Cudkowicz, T...

BACKGROUND Overexpression of epidermal growth factor receptor (EGFR) is found in many types of neoplasms. The aim of the study was to evaluate EGFR expression in colorectal cancer (CRC) specimens and to determine whether EGFR expression correlates with clinicopathological data and overall survival. PATIENTS AND METHODS Tissue specimens from 181 consecutive CRC patients treated at the Military...

In 1993, breast cancer will likely be diagnosed in more than 150000 women in the United States. In that group, those with axillary lymph node-negative (ANN) disease present one of the greatest dilemmas facing oncologists today. In this issue of the Journal, an article by Allred et al. (7) exemplifies an important trend in the search for a resolution to this problem—the use of this type of progn...

Estrogen receptor (ER) cx, a splice variant of ER , is a dominant repressor of ER function. In this study we investigated the possibility that because the progesterone receptor (PR) gene is a downstream target of activated ER , in ER -positive breast cancers, expression of ER cx would result in repression of PR. In ER -positive MCF-7 cells, stable transfection of an ER cx expression vector resu...

BACKGROUND The aim of this research was to study the levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in tumour tissue samples of colorectal carcinoma based upon immunohistochemical detection and compare those results with patients' outcome. METHODS Tumour blocks of patients surgically treated for colorectal cancer were evaluated by 8-oxodG immunohistochemical staining. The expression ...