We present a case of sarcoidosis complicated by total alopecia and a myopathy occurring in a young West Indian woman. There was a very satisfactory response to oral steroids.

In 1886 Hutchinson described the first case of alopecia totalis congenita associated with atrophy of the skin, and in 1904 Gilford reported a similar case and described it as premature senility (senilitas praecox) or progeria. From that time to the present about 20 cases have been described in the world literature (Curtin and Kotzen, 1929; Talbot, Butler, Pratt, MacLachlan and Tannheimer, 1945;...

From a group of 1,189 AA patients seen in our dermatology unit, thirteen (3 males, 10 females) experienced hair shedding that started profusely and diffusely over the entire scalp. They were under observation for about 5 years, histopathology and trichograms being performed in all instances. The mean age of the patients was 26.7 years. It took only 2.3 months on average from the onset of hair s...

Two sisters with primary hypergonadotrophic hypogonadism associated with alopecia totalis, streak ovaries, absent or rudimentary uterus and markedly hypo plastic internal and external genitalia are presented. Their parents were first cousins.

Hereditary vitamin D-resistant rickets type or vitamin D-dependent rickets type II is a genetically determined and rare autosomal recessive disorder, most often caused by mutations in the vitamin D receptor gene. It usually presents with rachitic changes not responsive to vitamin D treatment and the circulating levels of 1,25 (OH)2 vitamin D-3 are elevated, differentiating it from vitamin D-dep...

IMPORTANCE Previous studies found conflicting results as to whether atopic dermatitis (AD) is increased in patients with vitiligo and alopecia areata (AA). OBJECTIVE To compare the prevalence of AD between patients with either vitiligo or AA and those without these disorders by performing a meta-analysis of observational studies. DATA SOURCES MEDLINE, EMBASE, Cochrane Library, Google Schola...

Background: Alopecia areata is one of the most common human autoimmune disorders and its severe types are refractory to all conventional therapies. Corticosteroids have been used in severe alopecia areata since 1950s but there is concern over complications caused by high doses of corticosteroids. Methotrexate has been used as an adjunctive therapy in some autoimmune disorders and has been propo...

This comparatively new method of treatment has been used in various centres, with satisfactory results in the last two to three years. Conditions which are suitable for treatment are lichen planus, lichen simplex chronicus, discoid lupus erythematosus, granuloma annulare, alopecia areata, alopecia totalis, psoriasis, sarcoid of Boeck, keloid, eczema of various types, acute dermatitis medicament...

Vitamin D dependent rickets (VDDR) type 2 is a very rare hereditary disease which has an autosomal recessive mode of inheritance. Patients with VDDR have mutation in the gene encoding for vitamin receptor on chromosome 12q12-q14, thus averting normal physiological action 1,25 D. It's presents developmental delay motor domain features usually first year life. Alopecia totalis frequent associatio...

Alopecia areata is a prevalent autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body. It usually starts with one or more small, round, smooth patches on the scalp and can progress to total scalp hair loss (alopecia totalis) or complete body hair loss (alopecia universalis). The scalp is the most commonly affected area, but the beard or any hair-bearing sit...