Accumulating data demonstrated that hypercholesterolemia and oxidative stress play an important role in the development of atherosclerosis. In the present study, a protective activity of alpha-lipoic acid; a metabolic antioxidant in hypercholesterolemic-induced animals was investigated. Eighteen adult male New Zealand White (NZW) rabbit were segregated into three groups labelled as group N, HCD...

Background: Autophagy is a genetically and evolutionarily conserved programmed process that destroys long-lived cellular proteins organelles. Objectives: The aim of this study was to evaluate the effect eight weeks strength training with alpha-lipoic acid supplementation on Becline-1 malondialdehyde concentrations in elderly diabetic rats. Methods: In experimental study, 35 old male Wistar rats...

Background There are reports that indicate dietary alpha lipoic acid (ALA) supplementation enhances glucose uptake. The research was done with animal models and diabetic humans, but the effects of ALA supplementation on glucose uptake in healthy humans are unknown. The present study was designed to test the hypothesis that acute ingestion of ALA would enhance glucose uptake in healthy male subj...

BACKGROUND: Titanium dioxide nanoparticles (TiO2 NPs) uptake may primarily cause adverse effects by inducing oxidative stress, resulting in cell damage, genotoxicity, inflammation, and immune response. To date, there are limited studies investigating the effect of TiO2 NPs on liver health no found a naturally occurring compound able to ameliorate such effect. Thus, this study investigated alpha...

Atherosclerosis is arterial wall’s disease initiated by lipid retention, oxidation, and modification, provoking chronic inflmmation ultimately causing stenosis thrombosis. This study investigated the effect of alpha lipoic acid (ALA) on thoracic aorta type 2 diabetic rat. Fifteen adult male rat Rattus novergicus Wistar strain were separated into three groups (n=5), there labelled as control, di...

Objective: In the present study, we aimed to investigate morphological and biochemical effects of alpha-lipoic acid (ALA) on bladder injury caused by water avoidance stress (WAS) show its effect number degranulated mast cells, which increase after stress. Materials Methods: Wistar albino rats were subjected WAS animals in treatment group injected ALA. After urinary tissues routine tissue proces...

INTRODUCTION We investigated the role of oxidative stress in the pathogenesis of reexpansion pulmonary edema (RPE) and effect of alpha-lipoic acid (ALA) in the prevention of RPE. MATERIAL AND METHODS There were 4 groups consisting of 10 rats in each group; control group (CG), α-lipoic acid group (ALAG), reexpansion pulmonary edema group (RPEG), reexpansion pulmonary edema plus α-lipoic acid g...

Objective: Antioxidants, including alpha lipoic acid (ALA) and vitamin E, are efficacious for the treatment of nonalcoholic fatty liver disease (NAFLD). The objective was to evaluate the effects of ALA and vitamin E alone or combined as therapy for patients with NAFLD and nonalcoholic steatohepatitis (NASH). Design: Placebo-controlled, open-label, prospective study in which patients with NAFLD ...

Background and Objectives: Alpha-lipoic acid (ALA) is considered as a potent antioxidant with anti-inflammatory functions. Moreover, a number of studies have revealed its lipid lowering properties. Therefore, we aimed to examine the effect of ALA on serum lipids in women with rheumatoid arthritis (RA), who have high mortality rate mainly due to accelerated atherosclerosis. Materials and Method...