Objectives: The purpose of this study was to evaluate the effect of low dose doxycycline and atorvastatin on gingival inflammation and alveolar bone loss in an experimental model of periodontitis in rats. Methods: Forty male Sprague Dawley rats were divided into four study groups as follows: (I) experimental periodontitis control, (II) rats with periodontitis treated with low dose atorvastatin...

Objectives The first cause of tooth loss in developed countries is periodontitis. Chronic periodontitis is the most common form of periodontitis and it is characterized by loss of periodontal attachment, destruction of alveolar bone and eventual loss of teeth. Atorvastatin is a statin drug used for the treatment of high cholesterol. Statins can stop the inflammatory proc...

Bone loss in chronic periodontitis was assessed from panoramic radiographs by direct measurement from the cemento-enamel junction (CEJ) and by measuring the proportion of the tooth length supported by bone. Mesial and distal bone levels of all available teeth were assessed for 50 patients aged 30-39 years referred for periodontal treatment. 85% and 74% of surfaces were measurable by the proport...

objectives : bone assessment is essential for diagnosis, treatment planning and prediction of prognosis of periodontal diseases. however, two-dimensional radiographic techniques have multiple limitations, mainly addressed by the introduction of three-dimensional imaging techniques such as cone beam computed tomography (cbct). this study aimed to assess the accuracy of cbct for detection of marg...

We have invented a mouse model of periodontitis associated with alveolar bone loss induced by lipopolysaccharide. Ovariectomized (OVX) animals are widely used as a model for osteoporosis due to estrogen deficiency. To define the relationship between periodontitis and osteoporosis, we examined the influence of estrogen deficiency on the mouse alveolar bone mass. In OVX mice, bone loss was detect...

UNLABELLED Glucocorticoid (GC) treatment is the main cause of secondary osteoporosis. There are some controversies about the relationships between alveolar bone loss and bone loss at the appendicular and axial skeleton. OBJECTIVE To assess, in parallel, the effects of GCs on alveolar bone and on the tibia in a mice model. METHODS Five-month-old male Swiss-Webster mice were randomized into t...