Background: With increasing proportion of geriatric population, late-life co-morbidities including dementias, heart disease, arthritis and cancers are also steadily. Cognitive impairment, mainly affecting the is condition when a person has trouble remembering, learning new things, concentrating or making decisions that affect their everyday life, often considered precursor to more serious disea...

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The cholinergic deficit in Alzheimer’s disease (AD) remains the cornerstone for the understanding of chemical signal transfer. Hypofunctions of cholinergic systems are significantly involved in the signs and symptoms of senile dementia of the Alzheimer type. Cognitive deficits in AD have been widely associated with dysfunction of the cholinergic system. As a diagnostic marker of AD the activity...