assembly in particular is associated with a wide range of functions including cell division, cell motility and diseases such as Alzheimers' and Parkinsons'. The forces generated during the growth of native self-assemblies such as actin and microtubules is vital for cellular function. The generation of forces is achieved by a reversible polymerization of the constituent monomers (tubulin and act...

..................................................................................................... v Populärvetenskaplig sammanfattning ....................................................... vii Alzheimers sjukdom ................................................................................. vii Stress och allopregnanolon .....................................................................

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia worldwide. Apart from dominantly inherited mutations, age is the major risk factor and as life expectancy increases the prevalence for AD escalates dramatically. AD causes substantial problems for the affected persons and their families, and the society suffers economically. To date the available treat...

Amyloid protein aggregation is a key factor in the development of variety serious diseases humans, commonly named as amyloidoses (Alzheimers and Parkinsons diseases, type II diabetes, etc.), determinant protein-based inheritance lower eukaryotes. In yeast, translation termination Sup35 one most extensively studied amyloidogenic proteins. Aggregation (induction [PSI+] prion) decreases its functi...

Alzheimer’s disease (AD) and Parkinson’s disease (PD) pose significant challenges for successful development of new therapies, with anextremely high drug trial failure rate and yet no approved disease modifying drugs available. Given the magnitude of the challenges, it has become clear that larger collaborations and multi-partner joint efforts, pooling resources and expertise,are required for t...