Various isocyanide-based multicomponent reactions prove to be highly reliable when ?-substituted ?-amino boronic esters are employed as the amine component, allowing efficient synthesis of unprecedented peptidomimetics and heteroatom-rich boron-containing small molecules. In particular, scope Ugi reaction is widely exploited, give a family enantiopure ?-amido boronates. The Ugi-azide van Leusen...

In the title compound, C(9)H(11)ClN(2)O(3)S, the dihedral angle between the benzene ring and the amido -NHCO- plane is 15.0 (2)°. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal structure, the amino NH(2) group is involved in inter-molecular N-H⋯O hydrogen bonds, which connect the mol-ecules into a double layer structure expanding parallel to the bc plane. Th...

Three novel amido-alcohols were synthesized on the base of the camphane scaffold. Natural amino acids were transformed into their -hydroxy analogues with retention of configuration, and attached to bornylamine. The compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv. The activity shifts from micromolar to nanomolar inhibitory concentrations depending o...

In the title compound, C(10)H(12)N(2)O(5)S, one of the sulfonyl O atoms is hydrogen bonded to the amido N atom of an adjacent mol-ecule. There is also a weak hydrogen-bonding inter-action between the other sulfonyl O atom and the secondary amino N atom. In addition, the amido O atom is also hydrogen bonded to a carboxyl O atom. These hydrogen-bonding inter-actions give rise to a layer structure...

I. Amino Acids A. Alkylamino Acids: :-Alkylamino acids, L-proline, L-valine. B. Hydroxyamino Acids: L-Serine, L-threonine, D-allothreonine, L-isoserine. C. Amino-amino Acids: L-2,3-Diaminopropionic acid, L-2,4-diaminobutyric acid. D. Carboxyamino Acids: L-Aspartic acid, 3-amino-pentanedioic acids. E. Thioamino Acids: D-Penicillamine, DOr L-methylcysteine, L-cysteine, L-methionine. F. Amido-amin...

A new Pd-catalyzed reaction for the stereoselective synthesis of cyclopentane-fused benzocyclobutenes is described. These transformations likely proceed via carbamate-directed carbopalladation followed by intramolecular C-H activation of an alkylpalladium intermediate. The mechanistic relationship between these transformations and Pd-catalyzed reactions of gamma-(n-Boc-amino)alkenes with aryl b...

The present mechanistic study comprehensively explores alternative scenarios for activation of the amine-linked allene C=C linkage toward nucleophilic amido attack in the intramolecular hydroamination of a prototypical 1,3-disubstituted aminoallene by a well-characterised samarocene-amido catalyst. Firstly, the non-insertive mechanism by Scott featuring C-N ring closure with concomitant amino p...

In the crystal structure of the title Schiff-base, C(20)H(21)N(3)O(4), the amino group forms an N-H⋯O hydrogen bond to the acetyl group of an adjacent mol-ecule, forming a zigzag chain. The 2-hydr-oxy group is inter-nally hydrogen bonded to the amido group though an O-H⋯O hydrogen bond.

The membrane penicillinase (EC 3.5.2.6; penicillin amido-beta-lactamhydrolase) of Bacillus licheniforis 749/C, which appears to be an intermediate in the formation of the exoenzyme, is a phospholipoprotein that carries an NH2-terminal chain of 24 amino acids (only serine, glycine, aspartic acid, asparagine, glutamic acid, and glutamine) and a phosphatidylserine that is not present in the exoenz...

-An attempt has been made to synthesize nitrogenous clay minerals hydrothermally from silicaalumina gels in the presence of amino acids, namely glycine and lysine, The products have been characterized by X-ray powder diffraction, by analyses for C and N contents, and by their infrared spectra. Amino acid-montmorillonites have been prepared under hydrothermal conditions of 200-250~ and 1000 atm....