Reactivities of l-'r" chelates of aminopolycarboxylic acids with DNA were investigated by the DNA-sequencing technique using 32P 5'-endlabeled DNA fragments obtained from the human c-Ha-ras-1 protoon cogene, and the reaction mechanism was studied by electron spin reso nance spectroscopy. Ferric nitrilotriacetate (Fe3*-NTA) plus hydrogen peroxide caused strong DNA cleavage in the presence of alb...

Aminopolycarboxylic acids are ubiquitous in natural waters and wastewaters. They have the ability to form very stable water-soluble complexes with many metallic di- or trivalent ions. The iron complex nitrilotriacetic acid-Fe(III) (FeNTA) has been previously shown to increase drastically the rate of photo- and biodegradation of 2-aminobenzothiazole, an organic pollutant, by Rhodococcus rhodochr...

The superior efficacy of aminopolycarboxylic acid conjugated lipid nanoparticles over standard liposomal is described by Juan Chen, Gang Zheng et al. in their Research Article (e202218218). EDTA–lipid based fluidize the cell membrane a detergent-like manner and improve delivery to 25-fold. This novel nanoparticle design feature can be deployed across accelerate cancer nanomedicine drug delivery.

Ion-pairing high-performance liquid chromatography-ultraviolet (HPLC-UV) methods were developed to determine two commonly used chelating agents, ethylenediaminetetraacetic acid (EDTA) in Abilify® (a small molecule drug with aripiprazole as the active pharmaceutical ingredient) oral solution and diethylenetriaminepentaacetic acid (DTPA) in Yervoy® (a monoclonal antibody drug with ipilimumab as t...