Introduction: Amphetamine and methamphetamine are man-made materials. They were only used as drugs at the beginning, but gradually outspreaded as psychedelics because of their sympathomimetic effects. Different studies have shown that the frequency of amphetamine and methamphetamine abuse has been increasing; also, there is a close relationship in amphetamine and methamphetamine abuse with psyc...

We previously demonstrated that rats treated with repeated, intermittent amphetamine displayed enhanced amphetamine-mediated dopamine release in the striatum. In this study, we examined whether amphetamine pretreatment would elicit enhanced amphetamine-mediated dopamine release in a cultured cell line in the absence of intact synaptic connections. PC12 cells pretreated with 1 microM amphetamine...

BACKGROUND Numerous studies have indicated that serotonin (5-HT)1B receptor ligands affect the behavioral effects of psychostimulants (cocaine, amphetamine), including the reinforcing activities of these drugs. METHODS To substantiate a role for those receptors in incentive motivation for amphetamine, we used the extinction/reinstatement model to examine the effects of the 5-HT1B receptor lig...

objective: this study aimed to examine the effects of haloperidol and amphetamine on human startle response modulated by emotionally-toned film clips. method: sixty participants, in two groups (one receiving haloperidol and the other receiving amphetamine) were tested using electromyography (emg) to measure eye-blink muscle (orbicular oculi) while different emotions were induced by six 2-minute...

Repeated intermittent amphetamine enhances efflux of dopamine through the dopamine transporter in rat basal ganglia and through the norepinephrine transporter in rat pheochromocytoma PC12 cells. Extracellular Ca2+ is required for the detection of this enhancement in the rat. In this study, we examined the role of Ca2+ and Ca2+ channels in the enhanced amphetamine-induced dopamine efflux that de...

(+/-)-Phenylpropanolamine (PPA), a widely available anorectic and decongestant, was evaluated in several behavioral paradigms rhesus monkeys for central nervous system neurotoxicity rats. PPA (1-30 mg/kg intragastric) reduced food intake but not self-administered i.v. (0.3-10 mg/kg/injection) by experienced drug self-administration. (30-100 resulted amphetamine-like responding two of four train...

Effectiveness of Matrix Treatment on Depression and Temptation in Consumption Amphetamine Dependent Individuals

BACKGROUND: In response to the rising rate of treatment admissions related to illicit use of amphetamines (eg, methamphetamine), we examined the prevalence of amphetamine use among treatment-seeking, opioid-dependent adults, explored whether amphetamine users were as likely as nonamphetamine users to enroll in opioid-dependence treatment trials, and determined whether amphetamine users manifest...

The influence of adenosine receptor agonists and antagonists on amphetamine-induced conditioned place preference (CPP) was examined in male Wistar rats. Selective adenosine A1 receptor agonist, CPA, significantly reduced the acquisition of CPP induced by amphetamine. NECA (A2/A1 adenosine receptor agonist) produced similar effect, but selective A2 adenosine receptor agonist CGS 21680, attenuate...

Repeated, intermittent treatment of rats with amphetamine followed by a withdrawal period leads to an enhancement in amphetamine-induced dopamine release. We previously reported an increased stoichiometry of site 3-phospho-synapsin I and increased levels of phospho-Ser41-neuromodulin in striatum after repeated amphetamine. In this study, we examined whether the enhanced amphetamine-induced dopa...