The authors present a case of the death of a young female drug addict due to intracerebral hemorrhage. Liquid chromatography with mass spectrometry was instrumental in the identification and quantitative determination of amphetamine within an intracerebral hematoma that had persisted for 13 days. In view of the fact that the deceased was young, did not suffer from any detectable diseases, and t...

Introduction: Amphetamine and methamphetamine are man-made materials. They were only used as drugs at the beginning, but gradually outspreaded as psychedelics because of their sympathomimetic effects. Different studies have shown that the frequency of amphetamine and methamphetamine abuse has been increasing; also, there is a close relationship in amphetamine and methamphetamine abuse with psyc...

Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure to dependence. We compared adolescent and adult mice in their ability to develop behavioral sensitization to amphetamine following a singl...

Both the relationship between cocaine or amphetamine abuse and stroke as well as the pathomechanism of cocaine/amphetamineinduced stroke are still unclear. Whereas a recent study showed no association between cocaine abuse and ischemic stroke in young patients [1], others have described cocaineor amphetamine-related strokes [2–5]. Several pathomechanisms have been discussed in the literature: c...

repetitive transcranial magnetic stimulation (rtms) has been used widely in various psychiatric disorders like depression and schizophrenia. there have been some reports of its usefulness in alcohol dependence and substance use disorders. the present paper reviews the studies done using rtms in substance use disorders including alcohol and nicotine dependence. various studies done have been rev...

Use of amphetamine and methamphetamine is widespread in the general population and common among patients with psychiatric disorders. Amphetamines may induce symptoms of psychosis very similar to those of acute schizophrenia spectrum psychosis. This has been an argument for using amphetamine-induced psychosis as a model for primary psychotic disorders. To distinguish the two types of psychosis o...

CONTEXT The abuse of stimulant drugs is increasing in the western United States. Although numerous case reports and animal studies suggest a link with stroke, epidemiologic studies have yielded conflicting results. OBJECTIVE To test the hypothesis that young adults who abuse amphetamines or cocaine are at a higher risk of stroke. DESIGN, SETTING, AND PARTICIPANTS Using a cross-sectional des...

Studies conducted with nonhuman laboratory animals have consistently shown that atypical antipsychotics that are mixed dopamine and serotonin antagonists attenuate the discriminative-stimulus effects of amphetamine. In the present experiment, eight healthy humans learned to discriminate 15 mg of oral d-amphetamine. After acquiring the discrimination (i.e., > or = 80% correct responding on four ...

BACKGROUND Case reports suggest a relationship between amphetamine abuse/dependence and aortic dissection, but no population-based epidemiologic studies have examined this link. Our objective was to test the hypothesis that young adults with a diagnosis of amphetamine abuse/dependence would be at higher risk for aortic dissection after accounting for known risk factors. METHODS In this popula...