visceral leishmaniasis (vl) is usually treated with pentavalent antimonial drugs given alone or in combination with other drugs. the efficacy of these treatments is diminishing, however, and development of alternative treatments has been recommended.we studied 13 patients with leishmaniasis who were unresponsive to meglumine antimonate, at a dose of 20 mg/kg body weight/per day given for 30 day...

introduction : conventional amphotericin b is one of the antifungal choices as prophylactic and empiric treatment against fungal infections in febrile neutropenic patients. however the time of initiation, dosing and monitoring of drug adverse effects must be justified to maximize the efficacy and minimize the toxicities of this antifungal agent. methods : we conducted a prospective observationa...

The effects of treatment with aerosolized amphotericin B desoxycholate and aerosolized liposomal amphotericin B were evaluated in severely immunosuppressed rats with invasive pulmonary aspergillosis. Aerosol treatment with amphotericin B desoxycholate consisted of a single dose (60 min) with amphotericin B concentrations in the nebulizer reservoir of 1, 2 and 4 mg/mL, respectively. For liposoma...

OBJECTIVES The aim of the present study was to compare the efficacy of a nano form of amphotericin B deoxycholate with that of conventional amphotericin B deoxycholate for the treatment of visceral leishmaniasis. METHODS We have formulated nanoparticles (10-20 nM) from amphotericin B deoxycholate (1-2 microM) by applying high-pressure (150 argon) milling homogenization and have tested their e...

OBJECTIVES In the present study we evaluated the pharmacokinetics and toxicity of amphotericin B in immunomodulator tuftsin-loaded liposomes in a murine model. METHODS Stability of amphotericin B liposomes was tested by incubating one volume of liposomal formulations of amphotericin B with nine volumes of serum. The pharmacokinetics of amphotericin B in Candida albicans-infected mice treated ...