Twenty-five patients undergoing elective intraabdominal surgery received either 1 or 2 g of ampicillin together with 1 g of sulbactam intravenously before surgery. The peritoneal levels of the agent were measured. Both compounds penetrated peritoneal fluid readily; the mean percentage of penetration by ampicillin was 92%; that of sulbactam was 96%. After 1 g of each agent, the peritoneal levels...

The ampicillin-sulbactam combination was evaluated in vitro to determine the optimal susceptibility testing conditions among five combination ratios and four fixed concentrations of sulbactam. The organisms tested were markedly resistant to aminopenicillins and most other beta-lactams. The ratio of 2:1 is recommended to assure recognition of the ampicillin-sulbactam spectrum and minimize false-...

The pharmacokinetics of ampicillin and sulbactam, a new beta-lactamase inhibitor, were investigated in 16 patients undergoing prosthetic cardiac valve insertion. The combination of 2 g of ampicillin and 1 g of sulbactam was administered as perioperative prophylaxis intravenously over 3 to 6 days. Several serum pharmacokinetic parameters were similar for the two drugs after three intravenous dos...

Ampicillin/Sulbactam is a combination of antibiotics made up of ampicillin, a betalactam and Sulbactam, a betalactamase inhibitor introduced in the eighties. The most frequent used combination is Ampicillin/Sulbactam (ratio 2:1) although the two agents are not synergetic. Ampicillin/Sulbactam has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and an...

OBJECTIVE The safety and efficacy of ampicillin plus sulbactam were compared with those of cefoxitin in the treatment of women with pelvic inflammatory disease (PID). METHODS This single-site, randomized, prospective, third-party-blinded, comparative, parallel-treatment study enrolled 93 women with a diagnosis of PID. Patients were treated with either ampicillin/sulbactam (2 g/1 g, administer...

Penicillin class antibiotics have demonstrated varying degrees of in vivo and in vitro success when tested against Chlamydia trachomatis. The activity of ampicillin-sulbactam, an agent commonly utilized in the treatment of pelvic infections, was tested to ascertain if any antichlamydial activity is present. Up to six endocervical isolates of C. trachomatis were tested against each of five antib...

The pharmacokinetic behaviour of an ampicillin/sulbactam (2:1) combination was studied after intramuscular administration of a single dose (20 mg/kg body weight: 13.33 mg/kg of ampicillin and 6.67 mg/kg of sulbactam) to six sheep and six goats. The objective was to determine whether there were differences between sheep and goats in the disposition profiles of ampicillin and sulbactam. The dispo...

STUDY OBJECTIVE To evaluate the efficacy and cost of treatment with two beta-lactam/beta-lactamase-inhibitor combinations. DESIGN Retrospective, open-label multicenter study. SETTING Fifty-four hospitals across the United States. PATIENTS Eight hundred ninety patients with skin and soft tissue, intraabdominal, gynecologic, respiratory, urinary tract, or other infections that required pare...

BACKGROUND With antimicrobial resistance on the rise and few new agents in development, it is important to exercise prudent judgment when utilizing antimicrobials. The Antimicrobial Stewardship Program (ASP) is responsible for facilitating the appropriate use of antimicrobials at the institution. Restricted antimicrobials and select additional antimicrobials are monitored by the ASP team to det...

Ampicillin-sulbactam is a first-line therapy for pneumonia and mainly excreted by the kidney. It important to optimize dose dosing interval of ampicillin-sulbactam because in patients with decreased renal function low skeletal muscle mass, such as elderly, excess drug may burden function. In this study, we evaluated indices optimized based on pharmacokinetics (PK) pharmacodynamics theory elderl...