peri-ampullary and pancreatic head cancer can cause significant morbidity and mortality among gastrointestinal malignancies in human beings because of its important anatomy and physiology.[1] this tumor is responsible for about 150,000 deaths annually all over the world, and is categorized as the 5th leading causes of death among the malignancies. [2] pancreaticoduodenectomy (pd) is the complex...

CONTEXT Wirsungocele has recently been shown to be associated with acute recurrent, severe necrotizing pancreatitis and chronic pancreatitis or chronic pain in abdomen. Till to date there is no report on association of wirsungocele with an ampullary neuroendocrine tumor, and recurrent pancreatitis. CASE REPORT We report a first ever case of wirsungocele diagnosed on EUS, its association with ...

BACKGROUND An 18-year-old Turkish woman was referred with a 6-week history of rapidly enlarging cervical mass at the left side. CASE REPORT She was diagnosed of ampullary carcinoma for which pancreatoduodenectomy was performed 14 months ago. In our patient with a history of malignancy, a rapidly enlarging neck mass was considered a metastasis to the neck. Tumor resection was performed. Histop...

BACKGROUND Early ampullary cancers present with good prognosis. Pancreaticoduodenectomy (PD) has been standard treatment for ampullary cancers, but it remains high rate of postoperative complications. So there raises a discussion on the role of local ampullectomy for early ampullary cancers (mainly focusing on pT1). METHODS 89 patients with pT1 ampullary cancer who underwent surgical treatmen...

BACKGROUND/AIM Pancreatic cancer has a dismal prognosis. Ampullary cancer (defined as cancer of the ampulla of Vater or the distal common bile duct) has a better prognosis and is thought to be a biologically different tumor. The aim of this study was to find factors that could predict survival after radical (R-0) resection for pancreatic head and ampullary cancers. METHODS We analyzed clinica...

Bile acids are potential carcinogens in gastrointestinal cancer, and interact with nuclear and membrane receptors to initiate downstream signaling. The effect of TGR5 [also known as G protein-coupled bile acid receptor 1 (GPBAR1)] on cancer progression is dependent on the tissue where it is activated. In this report, the function of TGR5 expression in cancer was studied using a bioinformatic ap...

cases of ampullary lesions, differential diagnosis between tumors and inflammation by endoscopic findings is sometimes challenging. Even if operators have experience in endo-scopic techniques, diagnostic accuracy by gross morphology is only 67%. Although histologic evaluation of ampullary le-sions with forceps biopsy is performed during endoscopy, there is still a risk of false negativity for t...

BACKGROUND Carcinoid tumors are usually considered to have a low degree of malignancy and show slow progression. One of the factors indicating the malignancy of these tumors is their size, and small ampullary carcinoid tumors have been sometimes treated by endoscopic resection. CASE PRESENTATION We report a case of a 63-year-old woman with a minute ampullary carcinoid tumor that was 7 mm in d...

Context The neuroendocrine tumor of the ampulla of Vater represents a rare disease and, although the majority of them are indolent, this neoplasm has a relatively poor prognosis. A quarter of cases of ampullary neuroendocrine tumors have been detected in patients with neurofibromatosis type I (von Recklinghausen's disease). The biological behavior of ampullary neuroendocrine tumor shows no asso...