The concept of clinicopathologic dissociation is a neglected one in medicine. It refers to the unexpected, complete absence concordance between clinical picture and underlying histopathologic finding. recognition such phenomenon generally implies radically different treatment follow-up choices. A rare phenomenon, it can however be encountered, especially field dermatoncology dermatology at larg...

Authors' A Chicago, C Medical an Occupatio National In of Patholo 6Nutritional Genetics, Human Ser Correspon ology and G Room 3044 6829; E-ma

Aim: The paper proposes a novel risk assessment method ology for complex cyber-physical systems: proposed may assist assessors to: (a) assess the risks deriving from cyber and physical interactions among components; (b) prioritize control selection process mitigating these risks. Methods: To achieve this, we combine modify appropriately two recent ologies targeted to systems interactions, as un...

the objective of this study was to evaluate several drug combinations for intraperitoneal anaesthesia in laboratory rats. following dose determination of anaesthetics in a pilot study, 45 healthy adult male rats were randomly assigned in 9 treatment groups and received propofol (alone or in combination with xylazine, midazolam, or ketamine) or ketamine (in combination with xylazine, midazolam, ...

ology 2004; 101: 1409–16 8 Pandit JJ. The variable effect of low dose volatile anaesthetics on the acute ventilatory response to hypoxia in humans: a quantitative review. Anaesthesia 2002; 57: 632–43 9 Pandit JJ, Manning-Fox J, Dorrington KL, Robbins PA. Effects of subanaesthetic sevoflurane on ventilation. 2. The response to acute and sustained hypoxia in humans. Br J Anaesth 1999; 83: 210–6 1...

we studied the effects of a single ketamine injection in an experimental model of chronic hypernatraemia in rats. three groups, each of 20 male wistar rats were chosen for the experiment; the control group was given water and the test groups were given 1% (group 1) and 2% (group 2) nacl solutions for two weeks. all groups were fed with the same diet, containing about 0.5% salt. other living con...

Top is a most remarkable particle, even for a quark. A single top quark weighs 175 GeV/c 2 , about as much as an atom of gold. But unlike the gold atom, which can be disassembled into 79 protons, 79 electrons, and 118 neutrons, top seems indivisible, for we discern no structure at a resolution approaching 10 −18 m. Top's expected lifetime of about 0.4 yoctosecond (0.4× 10 −24 s) makes it by far...

In their case report in this issue of Pediatrics, Carspecken et al1 describe a child for whom the diagnosis of furosemide allergic hypersensitivity was delayed due to false-positive allergy alert overrides to other drugs. Although articles demonstrating the incidence and prevalence of alert fatigue are not new, I compliment Carspecken for the transparency as to how fatigue from falsepositive el...