OBJECTIVES Recently, thread-embedding therapy (TET) has been widely applied in Korean medicine for cosmetic purposes such as reducing skin wrinkles. An inserted thread was reported to have induced continuous stimulation, followed by support for connective tissue regeneration. However, the potential role of TET in hairgrowth has not yet been reported. METHODS We designed this study to evaluate...

Anagen effluvium, the shedding of anagen hair, leads to diffuse non-scarring alopecia. We report two cases of anagen effluvium in the same family secondary to the ingestion of tubers of Gloriosa superba, which contains the antimitotic alkaloid colchicine. Both patients developed anagen effluvium and gastroenteritis 1-2 weeks after consuming the tubers. In addition, one of them had bicytopenia, ...

Scalp involvement is a prominent and often the initial presentation in patients with psoriasis. Hair growth may be impaired with a hair loss and an increased telogen/anagen ratio. The aim of this study was to investigate the hair density and anagen/telogen ratio in psoriatic patients, using epiluminescence microscopy combined with digital image analysis (TrichoScan). Thirty psoriatic patients w...

Anagen effluvium is the abrupt loss of hair that are intheirgrowing phase (anagen) due to an event impairsthe mitotic or metabolic activity follicle.We reporting a femalepatient presenting with sudden onset hairfall since one week. She has history usage ofalbendazole 400mgtwice in day for 2months forhydatid cystin liver.No any otherrisk factors acute, severe hairfall.On examination, diffuse thi...

BACKGROUND It has been reported that collagenases (matrix metalloproteinase 2 [MMP-2] and matrix metalloproteinase 9 [MMP-9]) are associated with hair cycle, whereas the mechanism of the association is largely unknown. METHODS The mice were randomly allocated into four groups: saline, and 5, 10, and 15 nM SB-3CT. Immunohistochemical analysis was employed to examine MMP-2 and MMP-9 protein. Re...

Background Spermidine has been shown both in vitro and in mice models to have an anagen-prolonging effect on hair follicles (HFs). Objectives To evaluate the effects of a spermidine-based nutritional supplement on the anagen phase of HFs in healthy human subjects in a randomized, double-blind, placebo-controlled trial. Methods One hundred healthy males and females were randomized to receive...

BACKGROUND Thuja orientalis has been traditionally used to treat patients who suffer from baldness and hair loss in East Asia. The present study sought to investigate the hair growth-promoting activity of T. orientalis hot water extract and the underlying mechanism of action. METHODS After T. orientalis extract was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the h...

The hair follicle is a structure showing a very unique cycling of its epithelial components. It is innervated by an abundance of peptidergic nerves, and neuroendocrine cells occur within the epithelium or in close proximity to it. Recently, it has been suggested that hair growth may be regulated by neuropeptides. We therefore investigated the relationship of VIP receptor expression to intracell...

Our recent in vitro experiments suggest that fluvastatin may influence tyrosinase (key enzyme of melanogenesis) synthesis. The aim of the present study was to verify those findings in experiments, in vitro, in melanoma cell line, and in vivo, in mice. The expression of tyrosinase in B16F10 melanoma cell line, after induction of melanogenesis by UVB irradiation, was examined by Western blot anal...