The Siah proteins, mammalian homologues of the Drosophila Sina protein, function as E3 ubiquitin ligase enzymes and target a wide range of cellular proteins for degradation. Here, I investigate the in vivo function of the fly protein, Sina-Homologue (SinaH), which is highly similar to Sina. Flies that completely lack SinaH are viable and in combination with a mutation in the gene, Ebi, show an ...

background: hospitals generate relatively large quantities of wastewater that may contain various potentially hazardous ma­terials; therefore the proper management of hospital wastewater is essential. methods:   in this cross-sectional study, the quality and quantity of wastewater in the hospitals of tehran university of medi­cal sciences (tums), tehran, iran, were studied and the suitable meth...

We show that Tramtrack (TTK88) expression represses neuronal fate determination in the developing Drosophila eye. Phyllopod (PHYL) acts to antagonize this repression by a mechanism that requires Seven In Absentia (SINA) and is associated with decreased TTK88 protein levels, but not reduced ttk88 gene transcription or mRNA stability. We present evidence that SINA, PHYL, and TTK88 physically inte...

This paper examines the impact of the introduction of Sina Weibo, the most popular microblog in China, on the quality of drugs on the market. Using a unique data set on drug quality and Sina Weibo use, I explore the staggered diffusion of Sina Weibo across prefectures. I find that the number of bad drugs is decreasing in Sina Weibo use: if the Sina Weibo use is doubled, the number of bad drugs ...

introduction: nowadays, medical equipment is essential to provide health care services in hospitals. since 20% of the hospitals costs are devoted to providing such equipment, an appropriate management is required to maintain it. in this study it is intended to investigate the maintenance management of medical equipment in hospitals. methods and materials: it is a cross-sectional study. the popu...

INTRODUCTION At the time of disasters, hospitals are considered as one of the most important facilities which should provide emergency services continuously. The purpose of this study was to determine the functional vulnerability of Tehran hospitals in dealing with natural disasters. METHODS This cross-sectional study was conducted in educational hospitals of Tehran University of Medical Scie...

Sina Weibo, which was launched in 2009, is the most popular Chinese micro-blogging service. It has been reported that Sina Weibo has more than 400 million registered users by the end of the third quarter in 2012. Sina Weibo and Twitter have a lot in common, however, in terms of the following preference, Sina Weibo users, most of whom are Chinese, behave differently compared with those of Twitte...

Sina Weibo, China’s most popular microblogging platform, is currently used by over 500M users and is considered to be a proxy of Chinese social life. In this study, we contrast the discussions occurring on Sina Weibo and on Chinese language Twitter in order to observe two different strands of Chinese culture: people within China who use Sina Weibo with its government imposed restrictions and th...