objectives: this study designed to detect the prevalence of ovarian and/or adrenal hyperandrogenism in women with polycystic ovary syndrome (pcos).materials: one hundred pcos women included in this cross sectional study after informed consent and approval of the study by local institute ethical committee. diagnosis of pcos based on the rotterdam eshre criteria. studied women underwent complete ...

OBJECTIVE Androgen excess in women is associated with visceral adiposity. However, little is known on the mechanism through which androgen promotes visceral fat accumulation. METHODS To address this issue, female mice to chronic androgen excess using 5α-dihydrotestosterone (DHT) and studied the regulation of energy homeostasis was exposed. RESULTS DHT induced a leptin failure to decrease bo...

Disorders of androgen excess may coexist with disorders of androgen deficiency, such as Klinefelter syndrome, and can create diagnostic and therapeutic challenges.

Although the aetiology of polycystic ovary syndrome (PCOS) is still not known and the search for causative genes is proving elusive, it is generally agreed that hyperandrogenism is at the heart of the syndrome. Here, it is proposed that excess androgens are the root cause of PCOS starting from their influence on the female fetus in programming gene expression, producing the characteristic signs...

CONTEXT Polycystic ovary syndrome (PCOS) is a triad of anovulation, insulin resistance, and hyperandrogenism. Androgen excess may correlate with metabolic risk and PCOS consensus criteria define androgen excess on the basis of serum T. Here we studied the utility of the androgen precursor serum androstenedione (A) in conjunction with serum T for predicting metabolic dysfunction in PCOS. PATIE...

background: polycystic ovary syndrome (pcos) is one of the most common reproductive disorders in women. previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of pcos. objectives: in the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of test...