The "win at all costs" mentality fuels athletes to seek performance-enhancing substances, such as anabolic-androgenic steroids, to gain an advantage over their opponents. Nonathletes espouse this same attitude to "win" the battle of attractiveness. An enhanced understanding of anabolic-androgenic steroids and the motivations behind their abuse will arm pediatricians with the ability to engage t...

SYNOPSIS. The androgenic gland has been described in a variety of crustacean species—isopods, amphipods and decapods. It has been shown to play a role in the regulation of male differentiation and in the inhibition of female differentiation. Upon its application for endocrine manipulation, it inhibits female characteristics. Recently, the androgenic hormone from the isopod Armadillidium vulgare...

The androgenic gland in malacostracan crustacean species produces and secretes androgenic gland hormone, which is responsible for male sexual differentiation, such as the induction and development of male sexual traits, and in turn the suppression of female sexual traits. Marmorkrebs, Procambarus fallax forma virginalis, which was identified as the first parthenogenetic species in decapod crust...

Environmental androgens are a group of compounds that to date have received very little attention. In this study, a yeast-based androgen screen (YAS) was used to determine the level of in vitro androgenic activity in seven United Kingdom estuaries. Surface water, sediment pore water, and sediment particulate material solvent extracts collected from Southampton Water, the Thames, Mersey, Tees, T...

BackgroundSerum uric acid (SUA) has been found to be an independent risk factor for metabolic syndrome (MS). However, the reports pertaining link between levels among androgenic, non-androgenic (clinical) PCOS subjects are conflicting. Hence, it was aimed determine incidence of hyperuricmia and its association subjects.MethodologyA single centre hospital based cross-sectional study conducted in...

Androgenic status affects rat preadipocyte adipose conversion from two deep intra-abdominal (epididymal and perirenal) fat depots differently. The aim of this study was to establish whether these site-specific alterations of adipogenesis are related to altered expressions of the transcriptional factors regulating proliferation and differentiation of preadipocytes, c-myc and CCAAT/enhancer bindi...

There are several androgen deficiency models that can be used to study the effects of pro-androgenic agents such as Eurycoma longifolia (EL). Suitable model must be chosen so that the androgenic effects of the agents tested could be demonstrated. As an example, EL was postulated to produce androgenic effects by stimulating the testosterone release by the testes. This makes the orchidectomy rat ...

A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) co...

We report a 42-year-old male amateur body builder and user of anabolic androgenic steroids, who developed ARDS, acute kidney injury, and refractory supraventricular tachycardia. He required extracorporeal membrane oxygenation, continuous veno-venous hemodialysis, and catheter ablation. We believe that long-term anabolic androgenic steroid abuse predisposed the patient to multiple organ dysfunct...