The Guidelines of the American Thyroid Association (ATA) have long been, and continue to be, the “bible” for the treatment of thyroid disease. The latest edition is due out shortly (ormayhave just comeoutby the timeyouare reading this), anddespite its thoughtfuland complete approach to the nuances of managing thyroid diseasewithmultidisciplinary input fromnational leaders, questions of surgical...

The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alterna...