نتایج جستجو برای: angiogenic activity
تعداد نتایج: 1147308 فیلتر نتایج به سال:
Among the earliest and most important stages during tumorigenesis is the activation of the angiogenic process, an event that is termed the "switch to the angiogenic phenotype." We have developed an in vivo system that can reliably recapitulate the stages in tumor development that represent this transition. Using this model, we have harvested and studied tumor nodules that can be distinguished f...
Angiogenesis plays a key role in tumor growth and cancer progression. TIE-2-expressing monocytes (TEM) have been reported to critically account for tumor vascularization and growth in mouse tumor experimental models, but the molecular basis of their pro-angiogenic activity are largely unknown. Moreover, differences in the pro-angiogenic activity between blood circulating and tumor infiltrated T...
The objective of this research was to test the in vitro anti-angiogenic activity of auraptene, a coumarin from citrus peel oil. We tested the ability of auraptene to inhibit in vitro angiogenesis using vascular endothelial growth factor (VEGF)-induced human umbilical endothelial cells (HUVEC) growth stimulation. Auraptene was applied at concentrations between 0 μM and 1μM to HUVEC in the presen...
Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth factor that exhibits growth stimulation and cell/tissue protection on numerous cells and tissues. In...
anti-angiogenic/anxiolytic effect of chlordiazepoxide: evidence on dual activity for cancer patients
angiogenesis which is the recruitment of new blood vessels is a critical process in several chronic diseases and is an essential component of tumor or cancer progression. development of therapies aimed at inhibiting the angiogenesis, in combination with classical anti-cancer therapies, is among the most intensively studied approaches to treat the cancer. in this study the effect of chlordiazepo...
To investigate the in vivo angiogenic activity of placenta growth factor (PlGF) and its heterodimers with vascular endothelial growth factor (VEGF), the induction of neovascularization of these factors in the mouse cornea was studied. VEGF 165 is sufficiently potent to stimulate new capillary growth from the limbal vessels. PlGF 129 /VEGF 165 heterodimers also induce corneal neovascularization ...
The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formatio...
PURPOSE The present study considered the hypothesis that spontaneous neovascularization of the cornea of nude mice results from a local imbalance between angiogenic and anti-angiogenic factors. METHODS The presence of angiogenic and anti-angiogenic factors was revealed by exchanging orthotopic corneal allografts between nude BALB/c mice and normal (hirsute) euthymic BALB/c mice and observing ...
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