a series of angiotensin ii (a ii) receptor antagonist of some substituted 5-(biphenyl-4-ylmethyl) pyrazole were subjected to qsar analysis using hansch and fujita-ban model, by using combination of thermodynamic, electronic, spatial descriptor and presence or absence of substituent respectively. several qsar model were obtained using stepwise regression analysis. two models from both the method...

objective(s) four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. the effects of 5a and 5b on angiotensin receptors (at') and l-type calcium channels were investigated on isolated rat aorta. materials and methods aortic rings were pre-contracted with 1 pm angiotensin ii or 80 mm kcl and relaxant effects of losartan, nifedipine, 5a a...

Background: Controversial data concerning the elevation of serum angiotensin-converting enzyme in psoriasis are reported in the literature. In order to verify whether this abnormality exists in Iranian patients, we performed this study. Method: Serum angiotensin-converting enzyme level was measured in 40 psoriatics. According to clinical forms of psoriasis, patients were further divided into th...

purpose:  to determine whether angiotensin ii levels in aqueous humor is related to diabetes mellitus and to evaluate the effect of captopril. methods: in a case-control study, aqueous humor samples were obtained during cataract surgery from 58 eyes of 58 patients, of which 37 were diabetic. from these latter subjects, 16 had taken captopril (captopril group) and 21 had not taken any angiotensi...

the mechanisms of drug dependence and rewarding properties of opiates are not exactly known and several neurotransmitters seem to be involved. it is possible that the rennin-angiotensin system could interact with the opioid system, since it has been shown that angiotensin ii(ang) and ace inhibitors have analgesic, anticonvulsant and antidepression effects and in some cases they could antagonize...

angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. treatment with lisinopril as an angiotensin converting enzyme (ace) inhibitor, can be a reason of angioedema. here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. laryngeal oedema is a main cause of ...

conclusions garlic powder consumption can reduce blood pressure, yet in this model, it did not have an effect on the interaction between renin angiotensin system and nitric oxide inhibition. results at the beginning and at the end of experiments, systolic blood pressure was higher in the hypertensive groups than the normotensive group. however, at the end of the study, diastolic blood pressure ...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...

Angiotensin converting enzyme (ACE; OMIM: 106180) has an important role in the conversion of angiotensin I to angiotensin II and degradation of bradykinin. Genetic polymorphism I/D (rs4646994) in the gene encoding ACE has been well defined. To get more insight into the genetic structure of Iranian populations, the distribution of the ACE I/D polymorphism among Iranians was compared with each ot...