Objective(s) Four novel losartan analogues 5a-d were synthesized by connecting a dihydropyridine nucleus to imidazole ring. The effects of 5a and 5b on angiotensin receptors (AT') and L-type calcium channels were investigated on isolated rat aorta. Materials and Methods Aortic rings were pre-contracted with 1 pM Angiotensin II or 80 mM KCl and relaxant effects of losartan, nifedipine, 5a and...

G-protein-coupled receptors (GPCR) belong to a large family of molecules eliciting different responses variety signaling molecules. These participate in various physiological functions such as metabolism, growth, immune responses, inflammation, vision, taste, olfaction, and neurotransmission well pathologic including chronic inflammatory vascular diseases. Receptors contributing the biological ...

The article is a review of publications concerning historical perspectives the renin-angiotensin system. discovery its components presented in chronological order, beginning with initial identification renin and proceeding to subsequent discoveries angiotensin-converting enzyme 2, angiotensin- (1-7), Mas receptor.
 This paper presents modern classification system, dividing it into classica...

In December 2019, in the province of Hubei (Wuhan-China), there was an outbreak a coronavirus-associated pneumonia, called coronavirus disease 2019 (COVID 19).(1) SARS-CoV-2 enters cell by angiotensin-converting enzyme 2 (ECA 2) receptors that are expressed multiple organs, including testicular tissue.(2) Protein S is most likely primed transmembrane serine protease (TMPRSS2), which interacts w...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...

Coronaviruses (CoVs) are a group of viruses that induce infection in the respiratory and other systems in the human body. There are two coronaviruses that transmitted from animals to humans including severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (1). The novel coronavirus that appeared at first in Wuhan, China, in December 2019 was named as severe acut...

Angiotensin II increases and decreases arterial pressure by acting at angiotensin type 1 and type 2 receptors, respectively. Renovascular hypertensive rats exhibit a high level of activity of the peripheral and central renin-angiotensin system. Therefore, in the present study, we evaluated the effect of increasing the expression of angiotensin type 2 receptors in the solitary-vagal complex (nuc...