When expressed in Xenopus oocytes, the trout red cell anion exchanger tAE1, but not the mouse exchanger mAE1, elicited a transport of electroneutral solutes (sorbitol, urea) in addition to the expected anion exchange activity. Chimeras constructed from mAE1 and tAE1 allowed us to identify the tAE1 domains involved in the induction of these transports. Expression of tAE1 (but not mAE1) is known ...

www.chestpubs.org our data clearly show that patients with CLD undergoing major hepatic resection fall under a high-risk designation. With the decision to use prophylactic methods against VTE frequently predicated on an assessment of individual patient risk, this information may prove valuable when used in conjunction with the American College of Chest Physicians’ Evidence-Based Clinical Practi...

Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...

The present study was designed to examine the activity of the sodium-independent chloride-bicarbonate anion exchanger and the sodium-proton exchanger in erythrocytes of 30 normotensive and 35 hypertensive subjects and its relation to the previously reported decrease in erythrocyte pH. Erythrocyte cytosolic pH was measured by the pH-sensitive fluorescent probe 2'-7'-bis(2-carboxyethyl)- 5(6)-car...

The uptakes of molecular iodine and bromine by both strong acid cation (Dowex 50W-X4 and X8) and strong base anion (Dowex 1-X4 and X8) exchange resins have been studied in aqueous solutions at 25 degrees C. An empirical formula for the amount of solute taken up by the resin in mmol per gram of dry resin, Q, as a function of the solute concentration in M (mol dm(-3)), C, was derived. Direct prop...

Removal of chromium complex dye from aqueous solutions by sorption onto a weakly basic, acrylic matrix anion exchanger Purolite A845 and a strongly basic, polystyrene matrix anion exchanger Purolite A 500P has been investigated under various experimental conditions: the initial dye concentration, pH and temperature. The sorption of chromium complex dye proceeds as a result of miscellaneous inte...

Walsh SB, Borgese F, Gabillat N, Unwin RJ, Guizouarn H. Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis. Am J Physiol Renal Physiol 295: F343–F350, 2008. First published June 4, 2008; doi:10.1152/ajprenal.00587.2007.—Anion exchanger 1 (AE1) is encoded by SLC4A1 and mediates electroneutral anion exchange across cell membranes. It is the m...

Uptake of uranium (VI) ions using an anion exchanger resin, namely amberlite CG-400, was studied through this work in the presence of sulfate anions. Impact of various parameters including pH, contact time, initial concentration of uranium ions and intrusion with different anion contents (phosphate, chloride,sulfate, nitrate and fluoride) was examined on the sorption performance of the resin. A...

JGP study suggests the anion exchanger AE1 operates via an elevator-like mechanism.

Intracellular pH is maintained by a dynamic equilibrium balancing the opposing forces of proton loading and proton extrusion. By providing an efflux pathway for base, anion exchangers constitute a key component of the plasma membrane proton-loading machinery. The data in this paper identify a histidine-rich sequence within the cytoplasmic domain of the nonerythroid anion exchanger, AE2, that se...