In peripheral arterial disease (PAD) of the lower extremities, the presence of flow-limiting stenoses can be objectively detected by the ankle-brachial index (ABI). However, the severity of ischemic symptoms is not necessarily associated with the ABI value. Atherosclerotic plaque in lower extremity PAD induces ankle arterial stiffness and reduces ankle vascular resistance, which may decrease an...

Between 2002 and 2008, 130 consecutive ankles were replaced with an hydroxyapatite (HA) and titanium-HA-coated Ankle Evolutive System total ankle prosthesis. Plain radiographs were analysed by two independent observers. Osteolytic lesions were classified by their size and location, with cavities > 10 mm in diameter considered to be 'marked'. CT scanning was undertaken in all patients with marke...

Study population The study population comprised a hypothetical cohort of previously untreated 60-year-old patients presenting with severe unilateral claudication of at least one year in duration, who had at least one significant lesion (>50% arterial diameter reduction) that was located predominantly suprainguinal or infrainguinal, an ankle brachial index pressure of 0.70 and no history of coro...

BACKGROUND Cytokines have crucial role in the development and maintenance of inflammation and pain in arthritis. Activation of prostaglandin receptor subtype EP(4) suppresses cytokine production in immune cells. The purpose of this study was to evaluate whether a novel EP(4) agonist would be able to suppress thermal and mechanical hyperalgesia and paw swelling in acute and chronic phases in rat...

INTRODUCTION Much of the currently available data on the technical aspects of syndesmotic screw placement are based upon biomechanical studies, using cadaveric legs with different testing protocols, and on surgeon preference. The primary aim of this study was to investigate the effect of the level of syndesmotic screw insertion on functional outcome. Further, the effects of number of cortices e...

INTRODUCTION To investigate the connection between the intensity of initial symptoms of inflammation and locomotor outcome in rheumatoid arthritis, we examined the relationship between long-term locomotor abnormalities and signs of inflammation at the onset of the disease in adjuvant-induced arthritis (AIA) in rats. METHODS The arthritis score and hind-paw diameter were followed from immuniza...

objectives: this paper describes further improvement and preliminarily evaluation of a novel viscoelastic ankle-foot prosthesis prototype. the objective was to control the ankle hysteresis at slow and normal walking speeds. methods: inspired by the ankle biomechanics, in which the hysteresis differs based on the gait speeds, a manually damping control mechanism imbedded in the prosthesis for ad...

: investigating the mechanical behaviour of a healthy human ankle shows that it can be simulated by a mechanism composed of simple elements such as spring, and actuator. hence, appropriate design of this mechanism can be resulted to an artificial ankle that can help amputees properly. researches show that whatever the biomechanical behaviour of artificial ankle is similar to that of natural ank...

ankle sprains are among the most common injuries in athletes and military recruits. high bmi, previous history of ankle sprain, poor muscle strength, proprioceptive deficits, limitation in rom and balance are important risk factors for ankle sprain. recent studies have shown that external support such as brace and tape significantly reduces the risk of primary and recurrent ankle sprains in ath...