Since their introduction more than 30 years ago, calcium antagonists have emerged as one of the most attractive and widely used classes of antihypertensive agents. Of the 20 to 25 million patients receiving medication for hypertension in the United States, about one quarter are taking calcium antagonists. The wide appeal of the calcium antagonists is attributable to several features, including ...

Ott (1, 2) has shown that desoxypyridoxine (2,4-dimethyl-3-hydroxy5hydroxymethylpyridine) and methoxypyridoxine (2-methyl-3-hydroxy4-methoxymethyl-5-hydroxymethylpyridine), analogues of pyridoxine, act as pyridoxine antagonists in the chick. Because of our interest in the effects of metabolic antagonists on the development of the chick embryo (3), and on the behavior of mouse tumors growing on ...

A variety of receptors on pancreatic acinar and duct cells regulate both pancreatic exocrine secretion and intracellular processes. These receptors are potential sites of action for therapeutic agents in the treatment of pancreatitis. Cholecystokinin (CCK) receptor antagonists, which may reduce the level of metabolic "stress" on acinar cells, have been shown to mitigate the severity of acute pa...

objective: the present study aimed to review the relapse rate in patients with schizophrenia treated with orally taken atypical agents (serotonin dopamine antagonists, sdas) and depot preparation of conventional (typical) antipsychotics. methods: in this historical cohort study, mean relapse per month (mrm) index, duration between initiation of antipsychotic treatment and the first relapse epis...

“Atypical” antipsychotics are antagonists at serotonin 5-HT2A and dopamine d2 receptors. However, their effects on negative symptoms and cognitive deficits remain modest and they disrupt metabolic function. Recent drugs, such as aripiprazole, perospirone, bifeprunox, lurasidone and cariprazine act as D2 receptor antagonists (or partial agonists) combined with 5-HT1A receptor activation. The lat...

Two prime limiting factors in the treatment of neoplastic disease are (a) the toxicity of active anti-tumor agents for the host, and (b) the origin, during therapy, of resistance to the agent being employed. The origin of resistant variant sublines to therapy with folic acid antagonists, antipurines, glutamine antagonists, etc., has been amply demonstrated (5, 6, 22, 25-31, 86, 37). For purpose...