An investigation was undertaken to determine whether analgesics and their derivatives (13 compounds), and anti-inflammatory drugs (4 compounds) had mutagenicity. Rec-assay was used to clarify specific DNA-damaging properties, and the Ames test was used to find back-mutations, using S-9 fractions obtained from the liver of 4 animal species pretreated with polychlorobiphenyl. In the Rec-assay, sa...

---・-A micronucleus test using BDFi male mice was conducted in order to evaluate the in vive mutagenicity of mofezolac (N-22). N-22 was orally administered at doses of 75, 150, 300 arid 600 mglkg, with a sampling time of 24 hr. The frequency of polychromatic erythrocytes with micronuclei was O,07-O,08% in the groups treated with N-22 and did not differ markedly from that of the vehicle control ...

abstract   the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell wal...

Phytochemicals are versatile plant secondary metabolites with therapeutic properties. In this review, we explore lemongrass’s phytochemistry and pharmacological potential (Cymbopogon) as well its impact on gut microbiota. Lemongrass is well-known for antioxidant, anti-microbial, anti-inflammatory, anti-hypertensive, anti-diabetic, anti-mutagenicity, anxiolytic properties, hypoglycemic hypolipid...

ETHNOPHARMACOLOGICAL RELEVANCE Four species of Podocarpus are used in traditional medicine both in human and animal healthcare in South Africa. In vitro pharmacological screening of leaf and stem extracts of these species exhibited potent antimicrobial, anti-inflammatory, anti-tyrosinase, anthelmintic, acetylcholinesterase inhibitory and antioxidant activities. AIM OF THE STUDY To investigate...

Although the immunomodulatory effects of Astragali Radix extract (AR) have been documented, its anti-mutagenic activity, a problem arising from chemotherapeutic agents, is rarely reported. Therefore, and AR were investigated using cyclophosphamide (CPA)-induced immunosuppressed mouse model to develop an alternative agent. The fluid-bed-dried aqueous containing 37.5% dextrin exopolymers purified...

Quantum dots as nanocrystals of semiconductor materials are synthesized with different methods. The green synthesis fluorescent quantum using natural stabilizing agents has attracted much attention. This research aims to study the ability Teucrium polium L. extract synthesize silver (AgQDs). AgQDs was proved UV–Visible spectrophotometer, Fourier Transform Infrared spectroscopy (FTIR), X-Ray Dif...