Investigations in patients with thyroid disease led to the discovery of serum factors which react like antibodies with thyroglobulin-containing extracts of human thyroid gland (1, 2). These serum factors have been shown to be among the av-globulins (3). Pressman and colleagues (4) reported that the serum anti-thyroglobulin activity in one patient was associated with the y-macroglobulins. Korngo...

background: premature ovarian failure (pof) is a disorder of multi causal etiology. autoimmunity has been proposed as a mechanism for some cases of ovarian follicle dysfunction which is evident in pof. the aim of this study was to identify the level of auto-antibodies in pof and familial pof patients. materials and methods: in this study, auto-antibodies including anti-ovarian antibody (aoa), a...

BACKGROUND Anti-N-methyl-D-aspartate receptor encephalitis is an increasingly common autoimmune disorder mediated by antibodies to certain subunit of the N-methyl-D-aspartate receptor. Recent literatures have described anti-thyroid and infectious serology in this encephalitis but without follow-up. CASE PRESENTATION A 17-year-old Chinese female patient presented with psychiatric symptoms, mem...

OBJECTIVE To investigate the prevalence of autoimmune thyroid disease in diabetic children in Northwest Iran. METHODS In a cross-sectional study from February 2006 to November 2007, serum levels of anti-thyroid peroxidase, and anti-thyroglobulin antibodies, and thyrotropin hormone were measured with ELISA method in 176 diabetic children (78 Male and 98 Female) at a mean age of 8.3 +/- 3.7 and...

In vitro translation of the mRNA from the congenital goiter tissue of Afrikander cattle directs the synthesis of two (Mr congruent to 250,000 and congruent to 75,000, respectively) abnormal thyroglobulin-like polypeptides. Common features of these polypeptides are the following: 1) both are immunoprecipitated by purified, anti-thyroglobulin antibody; 2) the signal sequence is present on their n...

We compared two commercial assays for measurement of serum thyroglobulin [Nuclear Medical Systems (NMS) and "CIS" (Damon Diagnostics)] with each other and with one developed at Stanford (J Clin Endocrinol Metab 49:557-564, 1979). The NMS assay is a competitive-binding RIA, the CIS and Stanford assays are two-site immunoradiometric assays. The kit standards varied in thyroglobulin concentration....

OBJECTIVE Thyroid hormones influence the GH/IGF1 axis, but previous studies have reported discrepant results regarding serum IGF1 levels in hyperthyroidism. We have therefore investigated, at diagnosis, the relationship between serum IGF1 levels and the main characteristics of Graves' disease (GD): severity of hyperthyroidism, goiter size, presence of active Graves' ophthalmopathy (GO), antythy...