Background and Aim: Celiac Disease (CeD) is a multisystemic disease in addition to the small intestine, also affects liver. The spectrum of liver involvement CeD includes cryptogenic hypertransaminasaemia/cirrhosis, autoimmune diseases vascular like Non-cirrhotic portal fibrosis (NCPF). There lack systematic study on prevalence patients with NCPF. Methods: All new biopsy-proven NCPF reporting c...

BACKGROUND The prevalence of celiac disease is common in Iran. The aim of the present study was to determine the prevalence of celiac disease in apparently healthy blood donors of Sistan and Balouchestan Province, southeastern Iran. METHODS Serum samples of 1600 consecutive apparently healthy blood donors at Zahedan Blood Donation Center were assayed for anti-tissue transglutaminase (tTG) ant...

OBJECTIVE To determine celiac disease (CD) serology and rotavirus (RV) by polymerase reaction (PCR) in adults with non-specific gastrointestinal complaints. METHODS The study comprised 5176 randomly selected individuals living in Tehran, Iran between September 2006 and September 2007. Six hundred and seventy individuals with GI symptoms were identified with a questionnaire and invited for a f...

BACKGROUND AND AIMS Coeliac disease (CD) is characterised by the presence of autoantibodies against tissue transglutaminase (tTG), the endomysial autoantigen. This study was performed to determine the effect of purified autoantibodies on the enzymatic activity of tTG. METHODS Total IgA and IgG class antibodies and purified anti-tTG autoantibodies were isolated from sera of untreated patients ...

BACKGROUND & OBJECTIVES Several autoimmune disorders have been reported to be associated with autoimmune thyroiditis and may coexist with other organ-specific autoantibodies. The aim of the present study was to evaluate the presence of tissue transglutaminase (anti-TTG) and glutamic acid decarboxylase (anti-GAD) antibodies in patients suffering from autoimmune thyroiditis as diagnosed by anti-t...

AIMS To determine the prevalence of celiac disease (CD) in siblings of patients with this disease in Punjab, where wheat is the staple diet. METHODS Families of 80 patients with CD diagnosed as per modified ESPGAN criteria were offered family screening. Their siblings aged 2-15 years were tested for serum IgA anti-tissue transglutaminase antibody (anti-tTG) antibody. Those with positive or bo...

OBJECTIVES High prevalence rates of celiac disease in patients with Down syndrome have been reported in several countries. However, in Brazil there is no data regarding this association. In this study we report the prevalence of celiac disease in Down syndrome children and adolescents from southern Brazil. METHODS Seventy-one patients (32 female and 39 male, 2-18 years) from Curitiba, Brazil,...

BACKGROUND There is an association of celiac disease (CD) with several gastrointestinal illnesses. We aimed to determine the prevalence of CD in patients with inflammatory bowel disease (IBD) to evaluate the value of the routine serological tests for CD in these patients. MATERIALS AND METHODS patients with IBD underwent screening test for CD. The screening test was based on IgA anti-tTG anti...

To the Editor: In a recent issue of this journal, van der Sluijs Veer and Vermes (1 ) reported a high prevalence and concentration of IgG anti-tissue transglutaminase (anti-tTG) antibodies in patients with systemic lupus erythematosus (SLE) and increased antidsDNA antibodies, as well as in anti-SSA/SSB-positive patients. No increase was observed in patients with other autoantibodies, such as an...