The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested Elaeis guineensis Jacq (Arecaceae) methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that E. guineensis exhibits ex...

OBJECTIVES A new series of naphthyl substituted indazolonols 15-21 were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1H, D2O exchanged 1H and 13C NMR spectroscopic data. METHODS All the synthesized compounds 15-21 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida t...

Candida spp. are the most common causes of fungal infections worldwide. Among the Candida species, Candida albicans remains the predominant species that causes invasive candidiasis in most countries. In this study, we used two peptides, KABT-AMP and uperin 3.6 as templates to develop novel antifungal peptides. Their anticandidal activity was assessed using a combination of MIC, time-killing ass...

mon cause of fungal disease in humans. This fungus is known as the fourth leading cause of nosocomial infections. Over the last few decades, incidence of candidal infections due to C. albicans has been increasing, paralleling the growing numbers of immune-compromised patients. To the patients, disseminated candidiasis is sometimes a serious disease which often results in death. In addition, the...

The effect of SM-1213 [1,2-O-isopropylidene-3-O-3'-(N', N'-dimethylamino-n-propyl)-D-glucofuranose] on the candidastatic and candidacidal capacity of guinea pig peritoneal exudate cells was investigated. Phagocytes treated with SM-1213 demonstrated an enhanced ability to inhibit intracellular hyphal formation and elongation of Candida albicans cells as well as to reduce the percentage of viable...

The binding of several anticandidal peptides containing N3-(4-methoxyfumaroyl)-L-2,3-diaminopropanoic acid (FMDP) to serum proteins was studied using equilibrium dialysis. The affinity of these FMDP-peptides for serum albumin was low and well correlated with their biological activity against Candica albicans ATCC 26278 in serum albumin solution. This binding did not affect the biological activi...

Silver nanoparticles plays a vital role in the development of new antimicrobial substances against a number of pathogenic microorganisms. These nanoparticles due to their smaller size could be very effective as they can improve the antibacterial activity through lysis of bacterial cell wall. Green synthesis of metal nanoparticles using various plants and plant products has recently been success...

Gallic acid: An anticandidal compound in hydrolysable tannin extracted from the barks of Rhizophora apiculata BlumeLim Sheh Hong, Darah Ibrahim, Jain Kassim, Suraya Sulaiman