In this work we optimized the cooking and extraction conditions for obtaining high yields of total polyphenols from potato and studied the effect of three domestic methods of cooking on total phenols, antioxidant activity, and anticholinesterase activities. The optimization of the experiment was carried out by the experimental designs. The extraction of the polyphenols was carried out by macera...

  Alzheimer’s disease (AD) is a neurodegenerative disease that was characterized with deposit of beta amyloid (Aβ) aggregate in senile plaque. Oxidative damage to neurons and loss of cholinergic neurons in forebrain region are observed in this disease. Melissa officinalis is a medicinal plant from Lamiaceae family, used traditionally in the treatment of cognitive disorders. It has cholinomimeti...

The organophosphorus and carbamate insecticides inhibit cholinesterase, causing an increase of acetylcholine at neuromuscular junctions. Toxicosis due to anticholinesterase compounds can be diagnosed by finding depressed cholinesterase activity in the blood, brain, and/or retina. Cholinesterase activity < 50% of normal has been associated with significant exposure to an anticholinesterase agent...

Among the pathologic hypotheses of Alzheimer’s disease (AD), cholinergic deficit and oxidative stress have been implicated as two major hallmarks. Therefore, inhibition of cholinesterase and oxidation are the two promising strategies in the development of a drug for AD. Thunbergia grandiflora leaf extract (TGEx) is used in this research to investigate its anticholinesterase and antioxidant pote...

In the current study, a number of alkaloids including retamine, cytisine, and sparteine (quinolizidine-type), yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type) were tested in vitro for their inhibitory act...

Alzheimer hastalığı (AH) öncelikli olarak yaşlı popülasyonda görülen, klinik bellek ve bilişsel bozukluklar ile karakterize, ilerleyici nörodejeneratif bir hastalıktır. &#x0D; Hastalığın etiyolojisinin henüz tam belirlenememiş olması, hasta popülasyonunun yıllar geçtikçe artması, radikal tedavinin olmayışı, tedavi bakım maliyetinin oldukça yüksek hastaların yaşam kalitesini düşürmesi gibi sebep...

The use of the oxime P2S as intravenous therapy for organophosphorus anticholinesterase poisoning is well known. In emergency situations this route of administration may prove impractical due to severe symptoms of anticholinesterase poisoning and therefore the intramuscular route is to be preferred. The absolute intramuscular dose of P2S per man, recommended as necessary for adequate therapy of...