BACKGROUND A new group of oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban) with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. Patients being treated with oral anticoagulants are at higher risk for bleeding when undergoing dental treatments. MATERIAL AND METHODS A literature search was conducted...

a common complication of prosthetic heart valves is thrombosis. although the incidence of prosthetic valve thrombosis (pvt) in the tricuspid position is high, there are not enough data on the management of it, in contrast to left-sided pvt. here, we describe three cases of tricuspid pvt with three different management approaches: thrombolytic therapy; close observation with oral anticoagulants;...

Anticoagulants have long been used for prevention and treatment of arterial venous thromboembolism (VTE). Vitamin K antagonists (VKAs), especially warfarin, were decades as the only available oral anticoagulants.

The case of a 20 year old woman is reported with Budd-Chiari syndrome in whom lupus anticoagulant and anticardiolipin antibodies were shown; treatment with oral anticoagulants induced a considerable improvement. This treatment was interrupted after one year; interruption was followed by redevelopment of ascites. Further treatment with anticoagulants was continued for five years with noticeable ...

the mean percentage of cryptogenic strokes among ischemic strokes is 31%, of which one-third may be associated with patent foramen ovale. the foramen ovale is required for blood flow through the fetal atrial septum.  it is formed as of the fourth week of gestation, and this leads to right-left interatrial shunt that allows the passage of oxygenated blood to systemic circulation. in 75% of cases...

The object of this study was to see if the addition of anticoagulants to a regimen of cytotoxic drugs would improve the prognosis in patients with small cell carcinoma of the bronchus. Twenty-four patients were randomly allocated to receive chemotherapy or chemotherapy plus anticoagulants. The median survival in the group receiving the anticoagulants was not improved.

To assess the effects of oral contraceptives on anticoagulant treatment the prothrombin times of 12 patients were measured while they were taking both drugs simultaneously and while they were taking only anticoagulants. The mean prothrombin time ratio was significantly higher when patients were taking both drugs than when they were taking only anticoagulants and their doses of anticoagulant wer...

abstract:acute venous thromboembolism (vte) is a common disease associated with the significant morbidity and mortality. we reviewed clinical outcomes systematically with dabigatran as a direct oral anticoagulants (doac) for treatment of acute vte. we used ovide, pubmed, cochrane (central), embase, scopus, science direct, lilac(for article written not english) and also iranian database; magiran...