fresh frozen plasma (ffp) and prothrombin complex concentrate (pcc) reverse oral anticoagulants such as warfarin. we compared the standard dosage ffp and pcc in terms of efficacy and safety for patients with mechanical heart valves undergoing interventional procedures while receiving warfarin. fifty patients were randomized (25 for each group) with mechanical heart valves [international normali...

OBJECTIVE To explore the influence of enoxaparin on clinical events after percutaneous coronary intervention (PCI). METHODS We recruited 400 patients that had undergone the percutaneous coronary intervention without complications in the Cardiology Department of Changhai Hospital consecutively from May 2011 to December 2012. The patients were randomly assigned to receive anticoagulation therap...

Anticoagulation therapy was generally used in patients receiving mechanical mitral valve replacement. However, due to the increased risk of bleeding of anticoagulation therapy, it is important to control the International Normalized Ratio (INR) in a lower range to decrease the risk of bleeding. Therefore, the aim of this study was to investigate to which level the INR should be controlled and e...

Life-threatening bleeding in anticoagulation with Warfarin is an emergency challenging issue. Several approaches are available to treat bleeding in either over-anticoagulation or proper-anticoagulation, including vitamin K, fresh frozen plasma and prothrombin complex concentrates (PCC) administration. In coexisting trauma-induced bleeding and anticoagulation, reversal of anticoagulation must be...

CONTEXT Anticoagulation with warfarin requires careful management to avoid hemorrhage or thrombosis. The anticoagulation clinic has been suggested as a mechanism to reduce complications related to anticoagulation. OBJECTIVE To report our experience with anticoagulation complications, the cost of subsequent care, and the role of the anticoagulation clinic. DESIGN Sequential patients who were...

Significance of imaging The concept of “1-3-6-12 day rule” was recently mentioned as a consensus approach for recommendations for anticoagulation in patients with cerebral ischemic event, either transient ischemic attack or stroke. As mentioned by the authors, the initiation of anticoagulation in these patients depends on various factors. However, the decision to initiate or restart the anticoa...

Atrial fibrillation increases the risk of stroke 3to 5-fold and is implicated in about 15% of all strokes every year. Anticoagulation therapy has been proven to be efficacious in reducing incident stroke and systemic embolism in patients with atrial fibrillation and mechanical heart valves. However, the benefits of anticoagulation must be carefully weighed against the increased risk of intracra...

Prothrombin complex concentrate (PCC) is used for the rapid reversal of vitamin K antagonist (VKA) anticoagulation. PCC is also applicable in situations requiring rapid reversal of anticoagulation by non-vitamin K antagonist direct thrombin and factor Xa inhibitor oral anticoagulants (NOACs), thereby making PCC a general antidote for oral anticoagulation. In this chapter, the composition of dif...

Anticoagulation for atrial fibrillation has become more complex due to the introduction of new anticoagulant agents, the number and kinds of patients requiring therapy, and the interactions of those patients in the matrix of care. The management of anticoagulation has become a "team sport" involving multiple specialties in multiple sites of care. The American College of Cardiology, through the ...

BACKGROUND Lateral dural venous sinus thrombosis (LST) represents a serious complication of acute or chronic otitis media. It is thought to develop from the progression of inflammation and granulation tissue formation in the perisinus bone to infection of the sinus wall proper, with incitement of mural thrombosis. Treatment of LST typically includes the administration of broad-spectrum parenter...