This systematic review evaluated the animal and human evidence for pharmacomicrobiomics (PMx) interactions of antidepressant medications. Studies gut microbiota effects on functional behavioral antidepressants in models were identified from PubMed up to December 2022. Risk bias was assessed, results are presented as a following PRISMA guidelines. A total 28 (21 animal, 7 human) studies included...

Antidepressant agents inhibit the neuronal reuptake of monoamines such as serotonin (5-HT), noradrenaline (NA), and dopamine (DA). Several clinical and animal studies have advocated the use of these agents in the management of pain. In this study, therefore, the possibility of a correlation between the analgesic activity of six serotonin specific reuptake inhibitor (SSRI) antidepressants an...

Introduction Nowadays, the rates of antidepressant prescription are high and increasing. In this context, issue whether these medications addictive has been increasingly discussed. Objectives The aim review was to explore debate about property antidepressants. Methods We conducted a literature in Pubmed database, using search terms “antidepressants”, “SSRI”, “tricyclic”, “addiction”, “dependenc...

background: tricyclic antidepressants (tcas) poisoning is the most common poisoning in the poisoning emergency department of noor hospital, isfahan, iran. the objective of this study was to compare qrs interval duration with ravr³3mm and r/savr³ 0.7 in predicting: serious complications of acute tca toxicity. methods and materials: this study was descriptive – analytic and prospective cohort. tc...